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AG Jilek

 

FWF P22782:  A search for vertebrate peptides containing D-amino acids

As a subtle posttranslational modification, some natural peptides contain a D-amino acid with remarkable effect on their properties and biological function. We investigate the Chemistry of the conversion reaction and the resulting change in physico-chemical properties of the peptides. [read more]

Keywords:  peptide biosynthesis, chirality, D-amino acid, opioid peptide, isomerase, peptide antibiotic

 

Participants

Alexander Jilek (Project Leader)   

Farghaly Mohammed Farghaly Ali (Graduate Student)

 

Project-related publications

Gößler-Schöfberger R, Hesser G, Reif MM, Friedmann J, Duscher B, Toca-Herrera JL, Oostenbrink C, Jilek A.  A stereochemical switch in the aDrs model system, a candidate for a functional amyloid. Arch Biochem Biophys. 2012 Jun 15;522(2):100-6. [Link]

Gehmayr V, Mollay C, Reith L, Müller N, Jilek A. Tight binding of transition-state analogues to a peptidyl-aminoacyl-L/D-isomerase from frog skin. Chembiochem. 2011;12:1996-2000. doi: 10.1002/cbic.201100203. [Link]

Jilek A, Mollay C, Lohner K, Kreil G. Substrate specificity of a peptidyl-aminoacyl-L/D-isomerase from frog skin. Amino Acids. 2011 Mar 22. [Link]

Gössler-Schöfberger R, Hesser G, Muik M, Wechselberger C, Jilek A. An orphan dermaseptin from frog skin reversibly assembles to amyloid-like aggregates in a pH-dependent fashion. FEBS J. 2009;276:5849-59. [Link]

Zangger K, Gössler R, Khatai L, Lohner K, Jilek A. Structures of the glycine-rich diastereomeric peptides bombinin H2 and H4. Toxicon. 2008;52:246-54. [Link]

Jilek A, Mollay C, Tippelt C, Grassi J, Mignogna G, Müllegger J, Sander V, Fehrer C, Barra D, Kreil G. Biosynthesis of a D-amino acid in peptide linkage by an enzyme from frog skin secretions. Proc Natl Acad Sci U S A. 2005;102:4235-9. [Link]

 

Invited Reviews

Jilek A and Kreil G. D-Amino Acids in Animal Peptides. 2008; 139:1-5. [Link]


Schrift:

Universität Wien
Biologische Chemie
Prof. Dr. Christian Becker
Währinger Straße 38
1090 Wien

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