Publications Institut of Biological Chemistry (founded 2011)
Jancheva M, Boettcher T. A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus. Journal of the American Chemical Society. 2021 Jun 9;143(22):8344-8351. doi: 10.1021/jacs.1c01275
Kress T, Che K, Epasto LM, Kozak F, Negroni M, Olsen GL et al. A novel sample handling system for dissolution dynamic nuclear polarization experiments. Magnetic Resonance. 2021 Jun 4;2(1):387–394. doi: 10.5194/mr-2-387-2021
Prothiwa M, Filz V, Oehler S, Boettcher T. Inhibiting quinolone biosynthesis of Burkholderia. Chemical Science. 2021 May 28;12(20):6908-6912. doi: 10.1039/d0sc06167k
Ray RM, Hansen AH, Taskova M, Jandl B, Hansen J, Soemardy C et al. Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides. Beilstein Journal of Organic Chemistry. 2021 Apr 26;17:891-907. doi: 10.3762/bjoc.17.75
Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nature Reviews Drug Discovery. 2021 Apr 1;20(4):309-325. doi: 10.1038/s41573-020-00135-8
Niederacher G, Urwin D, Dijkwel Y, Tremethick DJ, Rosengren KJ, Becker CFW et al. Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology. 2021 Apr;2(2):537-550. doi: 10.1039/d0cb00175a
Dekan Z, Kremsmayr T, Keov P, Godin M, Teakle N, Durrauer L et al. Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science. 2021 Mar 21;12(11):4057-4062. doi: 10.1039/d0sc05501h
Penalver L, Schmid P, Szamosvari D, Schildknecht S, Globisch C, Sawade K et al. A Ligand Selection Strategy Identifies Chemical Probes Targeting the Proteases of SARS-CoV-2. Angewandte Chemie (International Edition). 2021 Mar 15;60(12):6799-6806. doi: 10.1002/anie.202016113
Balana AT, Levine PM, Craven TW, Mukherjee S, Pedowitz NJ, Moon SP et al. O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity. Nature Chemistry. 2021 Mar 15;13:441–450. doi: 10.1038/s41557-021-00648-8
Fruehwirth S, Egger S, Kurzbach D, Windisch J, Jirsa F, Flecker T et al. Ingredient-Dependent Extent of Lipid Oxidation in Margarine. Antioxidants. 2021 Jan 13;10(1):1-17. 105. doi: 10.3390/antiox10010105
Hackl S, Ng XW, Lu D, Wohland T, Becker CFW. Cytoskeleton-dependent clustering of membrane-bound prion protein on the cell surface. Journal of Biological Chemistry. 2021 Jan 1;296:100359. doi: 10.1016/j.jbc.2021.100359
Che K, Muttenthaler M, Kurzbach D. Conformational selection of vasopressin upon V1a receptor binding. Computational and Structural Biotechnology Journal. 2021 Jan;19:5826-5833. doi: 10.1016/j.csbj.2021.10.024
Kozak F, Kurzbach D. How to assess the structural dynamics of transcription factors by integrating sparse NMR and EPR constraints with molecular dynamics simulations. Computational and Structural Biotechnology Journal. 2021;19:2097-2105. doi: 10.1016/j.csbj.2021.04.020
Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB et al. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sciences. 2020 Dec 1;262:118436. doi: 10.1016/j.lfs.2020.118436
Dey A, Charrier B, Martineau E, Deborde C, Gandriau E, Moing A et al. Hyperpolarized NMR Metabolomics at Natural 13C Abundance. Analytical Chemistry. 2020 Nov 17;92(22):14867-14871. doi: 10.1021/acs.analchem.0c03510
Peschel A, Cardoso FC, Walker AA, Durek T, Stone MRL, Emidio NB et al. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency. Journal of Medicinal Chemistry. 2020 Nov 12;63(21):12773-12785. doi: 10.1021/acs.jmedchem.0c01107
Sicoli G, Kress T, Vezin H, Ledolter K, Kurzbach D. A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix-Loop-Helix Transcription Factor. The Journal of Physical Chemistry Letters. 2020 Nov 5;11(21):8944-8951. doi: 10.1021/acs.jpclett.0c02242
Mendel HC, Kaas Q, Muttenthaler M. Neuropeptide signalling systems - An underexplored target for venom drug discovery. Biochemical Pharmacology. 2020 Nov;181:114129. doi: 10.1016/j.bcp.2020.114129
Touchard A, Mendel HC, Boulogne I, Herzig V, Braga Emidio N, King GF et al. Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms. ACS Pharmacology and Translational Science. 2020 Oct 6;3(6):1211–1224. doi: 10.1021/acsptsci.0c00119
Reithofer M, Karacs J, Strobl J, Kitzmueller C, Polak D, Seif K et al. Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential-dependent NET-formation. The FASEB Journal. 2020 Oct;34(10):14024-14041. doi: 10.1096/fj.202001413R
Braga Emidio N, Brierley SM, Schroeder CI, Muttenthaler M. Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract. ACS Pharmacology and Translational Science. 2020 Aug 14;3(4):583-597. doi: 10.1021/acsptsci.0c00023
Liu H, Gruber CW, Alewood PF, Moller A, Muttenthaler M. The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene: including Oncogene Reviews. 2020 Aug 11;39:5917-5932. doi: 10.1038/s41388-020-01415-8
Hakala TA, Bialas F, Toprakcioglu Z, Breuer B, Baumann KN, Levin A et al. Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles. ACS Applied Materials and Interfaces. 2020 Jul 22;12(29):32951-32960. doi: 10.1021/acsami.0c09226
Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Venuganti VVK et al. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochemical Pharmacology. 2020 Jul;177:113948. doi: 10.1016/j.bcp.2020.113948
Gorka M, Zerko S, Konrat R, Kozminski W, Kurzbach D. 1H,
13C and
15N backbone resonance assignment of BRCA1 fragment 219–504. Biomolecular NMR Assignments. 2020 Jun 24;14:289–293. doi: 10.1007/s12104-020-09963-6
Emidio NB, Baik H, Lee D, Stuermer R, Heuer J, Elliott AG et al. Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications. 2020 Jun 14;56(47):6420-6423. doi: 10.1039/d0cc02321c
Szamosvari D, Prothiwa M, Dieterich CL, Boettcher T. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. Chemical Communications. 2020 Jun 14;56(47):6328-6331. doi: 10.1039/d0cc02498h
Weber EMM, Kress T, Abergel D, Sewsurn S, Azais T, Kurzbach D. Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR. Analytical Chemistry. 2020 Jun 2;92(11):7666-7673. doi: 10.1021/acs.analchem.0c00516
Szekely O, Olsen GL, Novakovic M, Rosenzweig R, Frydman L. Assessing Site-Specific Enhancements Imparted by Hyperpolarized Water in Folded and Unfolded Proteins by 2D HMQC NMR. Journal of the American Chemical Society. 2020 May 20;142(20):9267-9284. doi: 10.1021/jacs.0c00807
Ozcan A, Sahin D, Impellizzieri D, Nguyen TT, Hafner J, Yawalkar N et al. Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis. Journal of Investigative Dermatology. 2020 May;140(5):1003-1014.e8. e8. doi: 10.1016/j.jid.2019.09.018
Heuer J, Heuer F, Stuermer R, Harder S, Schlueter H, Emidio NB et al. The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions. International Journal of Molecular Sciences. 2020 Apr;21(7):2508. doi: 10.3390/ijms21072508
Toprakcioglu Z, Hakala TA, Levin A, Becker CFW, Bernandes GGL, Knowles TPJ. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions. Soft Matter. 2020 Mar 28;16(12):3082-3087. doi: 10.1039/c9sm02274k
Schilling PE, Kontaxis G, Dragosits M, Schiestl RH, Becker CFW, Maier I. Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites. RSC Advances . 2020 Mar 19;10(19):11079-11087. doi: 10.1039/d0ra01128b
Kalra J, Mangali S, Bhat A, Jadhav K, Dhar A. Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020 Mar 1;1866(3):165606. doi: 10.1016/j.bbadis.2019.165606
Olsen GL, Szekely O, Mateos B, Kaderavek P, Ferrage F, Konrat R et al. Sensitivity-enhanced three-dimensional and carbon-detected two-dimensional NMR of proteins using hyperpolarized water. Journal of Biomolecular NMR. 2020 Mar;74(2-3):161-171. doi: 10.1007/s10858-020-00301-5
Novakovic M, Olsen GL, Pinter G, Hymon D, Fuertig B, Schwalbe H et al. A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 Feb 4;117(5):2449-2455. doi: 10.1073/pnas.1916956117
Groß K, Kurzbach D, Angele CM. NMR for food profiling – Long Drink, Short Experiment: Ein interdisziplinärer Zugang zur Förderung von Urteilskompetenz. Haushalt in Bildung und Forschung. 2020;9(4):79-96. doi: 10.3224/hibifo.v9i4.06
Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood PF. On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe. Australian Journal of Chemistry. 2020;73(4):327-333. doi: 10.1071/CH19456
Conibear AC, Schmid A, Kamalov M, Becker CFW, Bello C. Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry. 2020;27(8):1174-1205. doi: 10.2174/0929867325666171123204851
Dürrauer L, Muratspahic E, Gattringer J, Keov P, Mendel HC, Pfleger KDG et al. I8-arachnotocin-an arthropod- derived G protein-biased ligand of the human vasopressin V-2 receptor. Scientific Reports. 2019 Dec 17;9(1):19295. doi: 10.1038/s41598-019-55675-w
Jin A-H, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ et al. Conotoxins: Chemistry and Biology. Chemical Reviews. 2019 Nov 13;119(21):11510-11549. doi: 10.1021/acs.chemrev.9b00207
Conibear AC, Rosengren KJ, Becker CFW, Kaehlig H. Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR. 2019 Nov;73(10-11):587-599. doi: 10.1007/s10858-019-00270-4
Hackl S, Becker CFW. Prion protein-Semisynthetic prion protein (PrP) variants with posttranslational modifications. Journal of Peptide Science. 2019 Oct;25(10):e3216. doi: 10.1002/psc.3216
Schlatzer T, Kriegesmann J, Schroeder H, Trobe M, Lembacher-Fadum C, Santner S et al. Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine. Journal of the American Chemical Society. 2019 Sep 18;141(37):14931-14937. doi: 10.1021/jacs.9b08279
Del Favero G, Bialas F, Grabher-Wusche S, Wittig A, Bräuer B, Gerthsen D et al. Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus. Chemical Communications. 2019 Aug 21;55(65):9649-9652. doi: 10.1039/c9cc02215e
Sadet A, Stavarache C, Bacalum M, Radu M, Bodenhausen G, Kurzbach D et al. Hyperpolarized Water Enhances Two-Dimensional Proton NMR Correlations: A New Approach for Molecular Interactions. Journal of the American Chemical Society. 2019 Aug 14;141(32):12448-12452. doi: 10.1021/jacs.9b03651
Jannin S, Dumez J-N, Giraudeau P, Kurzbach D. Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts. Journal of Magnetic Resonance. 2019 Aug;305:41-50. doi: 10.1016/j.jmr.2019.06.001
Kiryutin AS, Rodin BA, Yurkovskaya AV, Ivanov KL, Kurzbach D, Jannin S et al. Transport of hyperpolarized samples in dissolution-DNP experiments. Physical Chemistry Chemical Physics. 2019 Jul 7;21(25):13696-13705. doi: 10.1039/c9cp02600b
Sicoli G, Vezin H, Ledolter K, Kress T, Kurzbach D. Conformational tuning of a DNA-bound transcription factor. Nucleic Acids Research. 2019 Jun 4;47(10):5429-5435. doi: 10.1093/nar/gkz291
Poetgens AJG, Conibear AC, Altdorf C, Hilzendeger C, Becker CFW. Tumor-Targeting Immune System Engagers (ISErs) Activate Human Neutrophils after Binding to Cancer Cells. Biochemistry. 2019 Jun 4;58(22):2642-2652. doi: 10.1021/acs.biochem.9b00169