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Research

Synthesis and Semisynthesis of Membrane & Membrane Associated Proteins

  • Generating access to membrane embedded or associated proteins with rare and/or multiple posttranslational modifications
  • Analyzing these proteins and their modifications with respect to their role in protein folding, function and disease
  • Pushing the limits of chemical protein synthesis towards access of larger (membrane) proteins

Chem. Biol., 2007, 14, 994-1006.
Mol. BioSyst., 2008, 4, 733–740.
Bioconj. Chem.,2008, 19, 1938-1944.
Angew. Chem. Int. Ed., 2008, 47, 8215-8219.
Angew. Chem. Int. Ed., 2011, 50, 3988-3992.
FEBS Letters
2013, 587, 430-435.


Selective Protein Modification

  • Manipulation of protein properties by selective modification with polymers, glycans and other posttranslational modifications
  • Protein stabilization and construction of new scaffolds provide the basis for potential peptide- and protein-based therapeutics and diagnostics

ChemBioChem, 2006, 7, 891-895.
Bioconj. Chem., 2006, 17, 1492-1498.
Mol. BioSys., 2010, 6, 2423-2429..
Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 18367-18371.
ACS Chem. Biol. 2014, 9, 347-352.
Chem. Sci.
2014, 5, 1634-1641.


Immobilization of Functional Proteins

  • Attachment of (bio-) polymers and incorporation of posttranslational modifications to immobilize functional proteins on surfaces and in particles

Angew. Chem. Int. Ed., 2005, 44, 7635-7639.
ChemBioChem, 2007, 8, 32-36.
Angew. Chem. Int. Ed., 2007, 46, 4180-4183.
Chem. Com., 2008, 28, 3723-3725.
Chem. Sci. 2012, 3, 3500-3504.
ChemBioChem 2013, 14, 92-99.

 

Research cooperations

Within the University of Vienna:

L. González (Institut für Theoretische Chemie)

W. Schmid (Institut für Organische Chemie)

B. Keppler (Institut für Anorganische Chemie)

D. Marko (Institut für Lebensmittelchemie und Toxikologie)

R. Lemmens-Gruber (Department für Pharmakologie und Toxikologie)

H. Peterlik (Dynamics of Condensed Systems, Faculty of Physics)

 

In Vienna:

W. Knoll (Austrian Institute of Technology)

C. Gruber (Medizinische Universität Wien)

R. Konrat (Max-F.-Perutz Labor)


In Austria:

R. Breinbauer (TU Graz)


International:

Allergopharma – A business of MERCK

J. Buchner, M. Groll, M. Sattler (TU München, Germany)

T. Brück & S. Berensmeier (TU München, Germany)

R. Goody (Max-Planck Institut, Dortmund, Germany)

D. Harris (University of Boston, USA)

K. Moreman (University of Georgia)

C. Steegborn (Universität Bayreuth)

Syntab Therapeutics GmbH (Aachen, Germany)

 


Font:

University of Vienna
Biological Chemistry
Prof. Dr. Christian Becker
Währinger Straße 38
1090 Vienna

Office hours (Michaela Cherrier, Room 2H43):
Mon, Wed - Fri: 9 - 12 am, Thursday also 1.30 - 3.30 pm

T: +43-1-4277-705 01
University of Vienna | Universitätsring 1 | 1010 Vienna | T +43-1-4277-0