Publikationen Institut für Biologische Chemie (gegr. 2011)

Touchard A, Mendel HC, Boulogne I, Herzig V, Braga Emidio N, King GF et al. Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms. ACS Pharmacology and Translational Science. 2020 Okt 6;3(6):1211–1224. https://doi.org/10.1021/acsptsci.0c00119

Reithofer M, Karacs J, Strobl J, Kitzmueller C, Polak D, Seif K et al. Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential-dependent NET-formation. The FASEB Journal. 2020 Okt;34(10):14024-14041. https://doi.org/10.1096/fj.202001413R

Braga Emidio N, Brierley SM, Schroeder CI, Muttenthaler M. Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract. ACS Pharmacology and Translational Science. 2020 Aug 14;3(4):583-597. https://doi.org/10.1021/acsptsci.0c00023

Liu H, Gruber CW, Alewood PF, Moller A, Muttenthaler M. The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene: including Oncogene Reviews. 2020 Aug 11;39:5917-5932. https://doi.org/10.1038/s41388-020-01415-8

Hakala TA, Bialas F, Toprakcioglu Z, Breuer B, Baumann KN, Levin A et al. Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles. ACS Applied Materials and Interfaces. 2020 Jul 22;12(29):32951-32960. https://doi.org/10.1021/acsami.0c09226

Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Venuganti VVK et al. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochemical Pharmacology. 2020 Jul;177. 113948. https://doi.org/10.1016/j.bcp.2020.113948

Gorka M, Zerko S, Konrat R, Kozminski W, Kurzbach D. ¹H, ¹³C and ¹⁵N backbone resonance assignment of BRCA1 fragment 219–504. Biomolecular NMR Assignments. 2020 Jun 24;14:289–293. https://doi.org/10.1007/s12104-020-09963-6

Emidio NB, Baik H, Lee D, Stuermer R, Heuer J, Elliott AG et al. Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications. 2020 Jun 14;56(47):6420-6423. https://doi.org/10.1039/d0cc02321c

Szamosvari D, Prothiwa M, Dieterich CL, Boettcher T. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. Chemical Communications. 2020 Jun 14;56(47):6328-6331. https://doi.org/10.1039/d0cc02498h

Weber EMM, Kress T, Abergel D, Sewsurn S, Azais T, Kurzbach D. Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR. Analytical Chemistry. 2020 Jun 2;92(11):7666-7673. https://doi.org/10.1021/acs.analchem.0c00516

Szekely O, Olsen GL, Novakovic M, Rosenzweig R, Frydman L. Assessing Site-Specific Enhancements Imparted by Hyperpolarized Water in Folded and Unfolded Proteins by 2D HMQC NMR. Journal of the American Chemical Society. 2020 Mai 20;142(20):9267-9284. https://doi.org/10.1021/jacs.0c00807

Ozcan A, Sahin D, Impellizzieri D, Nguyen TT, Hafner J, Yawalkar N et al. Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis. Journal of Investigative Dermatology. 2020 Mai;140(5):1003-1014.e8. e8. https://doi.org/10.1016/j.jid.2019.09.018

Heuer J, Heuer F, Stuermer R, Harder S, Schlueter H, Emidio NB et al. The Tumor Suppressor TFF1 Occurs in Different Forms and Interacts with Multiple Partners in the Human Gastric Mucus Barrier: Indications for Diverse Protective Functions. International Journal of Molecular Sciences. 2020 Apr;21(7). 2508. https://doi.org/10.3390/ijms21072508

Toprakcioglu Z, Hakala TA, Levin A, Becker CFW, Bernandes GGL, Knowles TPJ. Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions. Soft Matter. 2020 Mär 28;16(12):3082-3087. https://doi.org/10.1039/c9sm02274k

Schilling PE, Kontaxis G, Dragosits M, Schiestl RH, Becker CFW, Maier I. Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites. RSC Advances . 2020 Mär 19;10(19):11079-11087. https://doi.org/10.1039/d0ra01128b

Kalra J, Mangali S, Bhat A, Jadhav K, Dhar A. Selective inhibition of PKR improves vascular inflammation and remodelling in high fructose treated primary vascular smooth muscle cells. Biochimica et Biophysica Acta - Molecular Basis of Disease. 2020 Mär 1;1866(3). 165606. https://doi.org/10.1016/j.bbadis.2019.165606

Olsen GL, Szekely O, Mateos B, Kaderavek P, Ferrage F, Konrat R et al. Sensitivity-enhanced three-dimensional and carbon-detected two-dimensional NMR of proteins using hyperpolarized water. Journal of Biomolecular NMR. 2020 Mär;74(2-3):161-171. https://doi.org/10.1007/s10858-020-00301-5

Novakovic M, Olsen GL, Pinter G, Hymon D, Fuertig B, Schwalbe H et al. A 300-fold enhancement of imino nucleic acid resonances by hyperpolarized water provides a new window for probing RNA refolding by 1D and 2D NMR. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2020 Feb 4;117(5):2449-2455. https://doi.org/10.1073/pnas.1916956117

Groß K, Kurzbach D , Angele CM. NMR for food profiling – Long Drink, Short Experiment: Ein interdisziplinärer Zugang zur Förderung von Urteilskompetenz. Haushalt in Bildung und Forschung. 2020;9(4):79-96. https://doi.org/10.3224/hibifo.v9i4.06

Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood PF. On-Resin Strategy to Label α-Conotoxins: Cy5-RgIA, a Potent α9α10 Nicotinic Acetylcholine Receptor Imaging Probe. Australian Journal of Chemistry. 2020;73(4):327-333. https://doi.org/10.1071/CH19456

Conibear AC, Schmid A, Kamalov M, Becker CFW, Bello C. Recent Advances in Peptide-Based Approaches for Cancer Treatment. Current Medicinal Chemistry. 2020;27(8):1174-1205. https://doi.org/10.2174/0929867325666171123204851

Dürrauer L, Muratspahic E, Gattringer J, Keov P, Mendel HC, Pfleger KDG et al. I8-arachnotocin-an arthropod- derived G protein-biased ligand of the human vasopressin V-2 receptor. Scientific Reports. 2019 Dez 17;9(1). 19295. https://doi.org/10.1038/s41598-019-55675-w

Jin A-H, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ et al. Conotoxins: Chemistry and Biology. Chemical Reviews. 2019 Nov 13;119(21):11510-11549. https://doi.org/10.1021/acs.chemrev.9b00207

Conibear AC, Rosengren KJ, Becker CFW , Kaehlig H. Random coil shifts of posttranslationally modified amino acids. Journal of Biomolecular NMR. 2019 Nov;73(10-11):587-599. https://doi.org/10.1007/s10858-019-00270-4

Hackl S, Becker CFW. Prion protein-Semisynthetic prion protein (PrP) variants with posttranslational modifications. Journal of Peptide Science. 2019 Okt;25(10). e3216. https://doi.org/10.1002/psc.3216

Schlatzer T, Kriegesmann J, Schroeder H, Trobe M, Lembacher-Fadum C, Santner S et al. Labeling and Natural Post-Translational Modification of Peptides and Proteins via Chemoselective Pd-Catalyzed Prenylation of Cysteine. Journal of the American Chemical Society. 2019 Sep 18;141(37):14931-14937. https://doi.org/10.1021/jacs.9b08279

Del Favero G, Bialas F, Grabher-Wusche S, Wittig A, Bräuer B, Gerthsen D et al. Silica particles with a quercetin-R5 peptide conjugate are taken up into HT-29 cells and translocate into the nucleus. Chemical Communications. 2019 Aug 21;55(65):9649-9652. https://doi.org/10.1039/c9cc02215e

Sadet A, Stavarache C, Bacalum M, Radu M, Bodenhausen G, Kurzbach D et al. Hyperpolarized Water Enhances Two-Dimensional Proton NMR Correlations: A New Approach for Molecular Interactions. Journal of the American Chemical Society. 2019 Aug 14;141(32):12448-12452. https://doi.org/10.1021/jacs.9b03651

Jannin S, Dumez J-N, Giraudeau P, Kurzbach D. Application and methodology of dissolution dynamic nuclear polarization in physical, chemical and biological contexts. Journal of Magnetic Resonance. 2019 Aug;305:41-50. https://doi.org/10.1016/j.jmr.2019.06.001

Kiryutin AS, Rodin BA, Yurkovskaya AV, Ivanov KL, Kurzbach D, Jannin S et al. Transport of hyperpolarized samples in dissolution-DNP experiments. Physical Chemistry Chemical Physics. 2019 Jul 7;21(25):13696-13705. https://doi.org/10.1039/c9cp02600b

Sicoli G, Vezin H, Ledolter K, Kress T, Kurzbach D. Conformational tuning of a DNA-bound transcription factor. Nucleic Acids Research. 2019 Jun 4;47(10):5429-5435. https://doi.org/10.1093/nar/gkz291

Poetgens AJG, Conibear AC, Altdorf C, Hilzendeger C, Becker CFW. Tumor-Targeting Immune System Engagers (ISErs) Activate Human Neutrophils after Binding to Cancer Cells. Biochemistry. 2019 Jun 4;58(22):2642-2652. https://doi.org/10.1021/acs.biochem.9b00169

Kress T, Walrant A, Bodenhausen G, Kurzbach D. Long-Lived States in Hyperpolarized Deuterated Methyl Groups Reveal Weak Binding of Small Molecules to Proteins. Journal of Physical Chemistry Letters. 2019 Apr 4;10(7):1523-1529. https://doi.org/10.1021/acs.jpclett.9b00149

Conibear AC, Thewes K, Groysbeck N, Becker CFW. Multifunctional Scaffolds for Assembling Cancer-Targeting Immune Stimulators Using Chemoselective Ligations. Frontiers in Chemistry. 2019 Mär 6;7. 113. https://doi.org/10.3389/fchem.2019.00113

Kamalov M, Kaehlig H , Rentenberger C, Müllner A, Peterlik H , Becker CFW. Ovalbumin Epitope SIINFEKL Self-Assembles into a Supramolecular Hydrogel. Scientific Reports. 2019 Feb 25;9(1). 2696. https://doi.org/10.1038/s41598-019-39148-8

Ellmer D, Brehs M, Haj-Yahya M, Lashuel HA, Becker CFW. Single Posttranslational Modifications in the Central Repeat Domains of Tau4 Impact its Aggregation and Tubulin Binding. Angewandte Chemie (International Edition). 2019 Feb 4;58(6):1616-1620. https://doi.org/10.1002/anie.201805238

Conibear AC, Watson EE, Payne RJ, Becker CFW. Native chemical ligation in protein synthesis and semi-synthesis. Chemical Society Reviews. 2018 Dez 21;47(24):9046-9068. https://doi.org/10.1039/c8cs00573g

Liutkeviciute Z, Gil-Mansilla E, Eder T, Casillas-Perez B, Di Giglio MG, Muratspahic E et al. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 2018 Dez;32(12):6808-6821. https://doi.org/10.1096/fj.201800443

Kamalov M, Capel PD, Rentenberger C, Müllner A, Peterlik H , Becker CFW. Silaffin-Inspired Peptide Assemblies Template Silica Particles with Variable Morphologies. Chemnanomat. 2018 Dez;4(12):1209-1213. https://doi.org/10.1002/cnma.201800340

Pfaff S, Nehring T, Pichler V, Cardinale J, Mitterhauser M, Hacker M et al. Development and evaluation of a rapid analysis for HEPES determination in ⁶⁸Ga-radiotracers. EJNMMI Research. 2018 Okt 23;8(1). 95. https://doi.org/10.1186/s13550-018-0449-6, https://doi.org/10.1186/s13550-018-0449-6

Herzig V, de Araujo AD, Greenwood KP, Chin YKY, Windley MJ, Chong Y et al. Evaluation of chemical strategies for improving the stability and oral toxicity of insecticidal peptides. Biomedicines. 2018 Sep 1;6(3). 90. https://doi.org/10.3390/biomedicines6030090

Feichtinger M, Sara T, Platzer G, Mateos B, Bokhovchuk F, Chène P et al. 1H, 13C, 15N resonance assignment of human YAP 50–171 fragment. Biomolecular NMR Assignments. 2018 Apr;12(1):179-182. https://doi.org/10.1007/s12104-018-9805-8

Conibear AC, Poetgens AJG, Thewes K, Altdorf C, Hilzendeger C, Becker CFW. Synthetic Cancer-Targeting Innate Immune Stimulators Give Insights into Avidity Effects. ChemBioChem: a european journal of chemical biology. 2018 Mär 2;19(5):459-469. https://doi.org/10.1002/cbic.201700522

Hufnagel B, Silberbauer K, Löppert R, Viernstein H, Praznik W, Müller M. Fermentation of non-digestible raffinose family oligosaccharides and galactomannans by probiotics. Trends in Food Science & Technology. 2018 Mär;9(3):1638-1646. https://doi.org/10.1039/c7fo01887h

Kamalov M, Hajradini A, Rentenberger C , Becker CFW. N-terminal residues of silaffin peptides impact morphology of biomimetic silica particles. Materials Letters. 2018 Feb 1;212:114-117. https://doi.org/10.1016/j.matlet.2017.10.050

Arrowsmith S, Keov P, Muttenthaler M, Gruber CW. Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development. Journal of Visualized Experiments. 2018 Jan;2018(131). e56639. https://doi.org/10.3791/56639

Matveenko M, Hackl S, Becker CFW. Utility of the Phenacyl Protecting Group in Traceless Protein Semisynthesis through Ligation-Desulfurization Chemistry. ChemistryOpen. 2018 Jan;7(1):106-110. https://doi.org/10.1002/open.201700180

Brehs M, Poetgens AJG, Steitz J, Thewes K, Schwarz J, Conibear AC et al. Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation. Scientific Reports. 2017 Dez 14;7. 17592. https://doi.org/10.1038/s41598-017-17627-0

Muttenthaler M, Andersson A, Vetter I, Menon R, Busnelli M, Ragnarsson L et al. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling. 2017 Dez 5;10(508). eaan3398. https://doi.org/10.1126/scisignal.aan3398

Gell AL, Groysbeck N, Becker CFW, Conibear AC. A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold. Journal of Peptide Science. 2017 Dez;23(12):871-879. https://doi.org/10.1002/psc.3051