Publikationen

Hanna C, Kriegesmann J, Dowman L, Becker C, Payne RJ. Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angewandte Chemie (International Edition). 2022 Apr 4;61(15):e202111266. doi: 10.1002/anie.202111266

Schmid P, Peñalver L, Böttcher T. A ligand selection strategy to customize small molecule probes for activity-based protein profiling (LS-ABPP). in Carlson EE, Hrsg., Chemical Microbiology Part A. Elsevier. 2022. S. 23-58. (Methods in Enzymology, Band 664). doi: 10.1016/bs.mie.2022.01.008

Kremsmayr T, Muttenthaler M. Fmoc Solid Phase Peptide Synthesis of Oxytocin and Analogues. in Werry EL, Reekie TA, Kassiou M, Hrsg., Oxytocin: Methods and Protocols. 1 Aufl. Band 2384. Humana Press, Springer. 2022. S. 175-199. (Methods in Molecular Biology, Band 2384). doi: 10.1007/978-1-0716-1759-5_11

Klein K, Garkov D, Rütschlin S, Böttcher T, Schreiber F. QSDB—a graphical Quorum Sensing Database. Database: The Journal of Biological Databases and Curation. 2021 Nov 26;2021:baab058. doi: 10.1093/database/baab058

Klein K, Garkov D, Ruetschlin S, Boettcher T, Schreiber F. QSDB-a graphical Quorum Sensing Database (vol 2021, baab058, 2021). Database: The Journal of Biological Databases and Curation. 2021 Nov 26;2021:baab071. doi: 10.1093/database/baab071

Böttcher T, Nguyen THN, Szamosvari D. Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives. ARKIVOC. 2021 Nov 12;2021(9):218-239. doi: 10.24820/ark.5550190.p011.547

Muratspahic E, Retzl B, Dürrauer L, Freissmuth M , Becker CFW, Gruber CW. Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor. Frontiers in Pharmacology. 2021 Okt 22;12:773029. doi: 10.3389/fphar.2021.773029

Negroni M, Kurzbach D. Residue-resolved monitoring of protein hyperpolarization at sub-second time resolution. Communications Chemistry. 2021 Okt 22;4(1):147. doi: 10.1038/s42004-021-00587-y

von Baeckmann C, Rubio GMDM, Kaehlig H , Kurzbach D , Reithofer MR , Kleitz F. Evaporation-Induced Self-Assembly of Small Peptide-Conjugated Silica Nanoparticles. Angewandte Chemie (International Edition). 2021 Okt 11;60(42):22700-22705. Epub 2021 Sep 14. doi: 10.1002/anie.202108378

Bialas F, Reichinger D, Becker CFW. Biomimetic and biopolymer-based enzyme encapsulation. Enzyme and microbial Technology. 2021 Okt;150:109864. doi: 10.1016/j.enzmictec.2021.109864

Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P et al. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology. 2021 Okt;161(4):1245-1256. Epub 2021 Jun 16. doi: 10.1053/j.gastro.2021.06.024

Bialas F, Becker CFW. Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase. Bioconjugate Chemistry. 2021 Aug 18;32(8):1742-1752. doi: 10.1021/acs.bioconjchem.1c00260

Vogl DP, Conibear AC, Becker CFW. Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins. RSC Chemical Biology. 2021 Aug;2(5):1441-1461. doi: 10.1039/d1cb00045d

Epasto LM, Georges T, Selimovic A, Guigner J-M, Azais T, Kurzbach D. Formation and Evolution of Nanoscale Calcium Phosphate Precursors under Biomimetic Conditions. Analytical Chemistry. 2021 Jul 27;93(29):10204-10211. doi: 10.1021/acs.analchem.1c01561

Emidio NB, Meli R, Tran HNT, Baik H, Morisset-Lopez S, Elliott AG et al. Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. Journal of Medicinal Chemistry. 2021 Jul 18;64(13):9484-9495. doi: 10.1021/acs.jmedchem.1c00767

Emidio NB, Tran HNT, Andersson A, Dawson PE, Albericio F, Vetter I et al. Improving the Gastrointestinal Stability of Linaclotide. Journal of Medicinal Chemistry. 2021 Jun 24;64(12):8384-8390. doi: 10.1021/acs.jmedchem.1c00380

Jancheva M, Boettcher T. A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus. Journal of the American Chemical Society. 2021 Jun 9;143(22):8344-8351. doi: 10.1021/jacs.1c01275

Kress T, Che K, Epasto LM, Kozak F, Negroni M, Olsen GL et al. A novel sample handling system for dissolution dynamic nuclear polarization experiments. Magnetic Resonance. 2021 Jun 4;2(1):387–394. doi: 10.5194/mr-2-387-2021

Prothiwa M, Filz V, Oehler S, Boettcher T. Inhibiting quinolone biosynthesis of Burkholderia. Chemical Science. 2021 Mai 28;12(20):6908-6912. doi: 10.1039/d0sc06167k

Ray RM, Hansen AH, Taskova M, Jandl B, Hansen J, Soemardy C et al. Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides. Beilstein Journal of Organic Chemistry. 2021 Apr 26;17:891-907. doi: 10.3762/bjoc.17.75

Lang M, Gasche C. Intestinales Mikrobiom und Malignome. in Stange E, Hrsg., Intestinales Mikrobiom und Innere Medizin. 1 Aufl. UNI-MED Verlag AG. 2021. S. 134-140

Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nature Reviews Drug Discovery. 2021 Apr 1;20(4):309-325. doi: 10.1038/s41573-020-00135-8

Niederacher G, Urwin D, Dijkwel Y, Tremethick DJ, Rosengren KJ, Becker CFW et al. Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology. 2021 Apr;2(2):537-550. doi: 10.1039/d0cb00175a

Dekan Z, Kremsmayr T, Keov P, Godin M, Teakle N, Durrauer L et al. Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science. 2021 Mär 21;12(11):4057-4062. doi: 10.1039/d0sc05501h

Penalver L, Schmid P, Szamosvari D, Schildknecht S, Globisch C, Sawade K et al. A Ligand Selection Strategy Identifies Chemical Probes Targeting the Proteases of SARS-CoV-2. Angewandte Chemie (International Edition). 2021 Mär 15;60(12):6799-6806. doi: 10.1002/anie.202016113

Balana AT, Levine PM, Craven TW, Mukherjee S, Pedowitz NJ, Moon SP et al. O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity. Nature Chemistry. 2021 Mär 15;13:441–450. doi: 10.1038/s41557-021-00648-8

Fruehwirth S, Egger S, Kurzbach D, Windisch J, Jirsa F, Flecker T et al. Ingredient-Dependent Extent of Lipid Oxidation in Margarine. Antioxidants. 2021 Jan 13;10(1):1-17. 105. doi: 10.3390/antiox10010105

Hackl S, Ng XW, Lu D, Wohland T, Becker CFW. Cytoskeleton-dependent clustering of membrane-bound prion protein on the cell surface. Journal of Biological Chemistry. 2021 Jan 1;296:100359. doi: 10.1016/j.jbc.2021.100359

Che K, Muttenthaler M , Kurzbach D. Conformational selection of vasopressin upon V_1a receptor binding. Computational and Structural Biotechnology Journal. 2021 Jan;19:5826-5833. doi: 10.1016/j.csbj.2021.10.024

Kozak F , Kurzbach D. How to assess the structural dynamics of transcription factors by integrating sparse NMR and EPR constraints with molecular dynamics simulations. Computational and Structural Biotechnology Journal. 2021;19:2097-2105. doi: 10.1016/j.csbj.2021.04.020

Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB et al. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sciences. 2020 Dez 1;262:118436. doi: 10.1016/j.lfs.2020.118436

Dey A, Charrier B, Martineau E, Deborde C, Gandriau E, Moing A et al. Hyperpolarized NMR Metabolomics at Natural 13C Abundance. Analytical Chemistry. 2020 Nov 17;92(22):14867-14871. doi: 10.1021/acs.analchem.0c03510

Peschel A, Cardoso FC, Walker AA, Durek T, Stone MRL, Emidio NB et al. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency. Journal of Medicinal Chemistry. 2020 Nov 12;63(21):12773-12785. doi: 10.1021/acs.jmedchem.0c01107

Sicoli G, Kress T, Vezin H, Ledolter K, Kurzbach D. A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix-Loop-Helix Transcription Factor. The Journal of Physical Chemistry Letters. 2020 Nov 5;11(21):8944-8951. doi: 10.1021/acs.jpclett.0c02242

Mendel HC, Kaas Q, Muttenthaler M. Neuropeptide signalling systems - An underexplored target for venom drug discovery. Biochemical Pharmacology. 2020 Nov;181:114129. doi: 10.1016/j.bcp.2020.114129

Boettcher T. Unveiling the Hidden Theatre of Microbes. ChemBioChem: a european journal of chemical biology. 2020 Okt 15;21(20):2869-2869. doi: 10.1002/cbic.202000554

Touchard A, Mendel HC, Boulogne I, Herzig V, Braga Emidio N, King GF et al. Heterodimeric Insecticidal Peptide Provides New Insights into the Molecular and Functional Diversity of Ant Venoms. ACS Pharmacology and Translational Science. 2020 Okt 6;3(6):1211–1224. doi: 10.1021/acsptsci.0c00119

Reithofer M, Karacs J, Strobl J, Kitzmueller C, Polak D, Seif K et al. Alum triggers infiltration of human neutrophils ex vivo and causes lysosomal destabilization and mitochondrial membrane potential-dependent NET-formation. The FASEB Journal. 2020 Okt;34(10):14024-14041. doi: 10.1096/fj.202001413R

Braga Emidio N, Brierley SM, Schroeder CI, Muttenthaler M. Structure, Function, and Therapeutic Potential of the Trefoil Factor Family in the Gastrointestinal Tract. ACS Pharmacology and Translational Science. 2020 Aug 14;3(4):583-597. doi: 10.1021/acsptsci.0c00023

Liu H, Gruber CW, Alewood PF, Moller A, Muttenthaler M. The oxytocin receptor signalling system and breast cancer: a critical review. Oncogene: including Oncogene Reviews. 2020 Aug 11;39:5917-5932. doi: 10.1038/s41388-020-01415-8

Hakala TA, Bialas F, Toprakcioglu Z, Breuer B, Baumann KN, Levin A et al. Continuous Flow Reactors from Microfluidic Compartmentalization of Enzymes within Inorganic Microparticles. ACS Applied Materials and Interfaces. 2020 Jul 22;12(29):32951-32960. doi: 10.1021/acsami.0c09226

Mangali S, Bhat A, Jadhav K, Kalra J, Sriram D, Venuganti VVK et al. Upregulation of PKR pathway mediates glucolipotoxicity induced diabetic cardiomyopathy in vivo in wistar rats and in vitro in cultured cardiomyocytes. Biochemical Pharmacology. 2020 Jul;177:113948. doi: 10.1016/j.bcp.2020.113948

Braga Emidio N, Baik H, Lee D, Stuermer R, Heuer J, Elliott AG et al. Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action (vol 75, pg 5602, 2020). Chemical Communications. 2020 Jun 28;56(51):7049-7049. doi: 10.1039/d0cc90250k

Gorka M, Zerko S, Konrat R, Kozminski W, Kurzbach D. ¹H, ¹³C and ¹⁵N backbone resonance assignment of BRCA1 fragment 219–504. Biomolecular NMR Assignments. 2020 Jun 24;14:289–293. doi: 10.1007/s12104-020-09963-6

Emidio NB, Baik H, Lee D, Stuermer R, Heuer J, Elliott AG et al. Chemical synthesis of human trefoil factor 1 (TFF1) and its homodimer provides novel insights into their mechanisms of action. Chemical Communications. 2020 Jun 14;56(47):6420-6423. doi: 10.1039/d0cc02321c

Szamosvari D, Prothiwa M, Dieterich CL, Boettcher T. Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia. Chemical Communications. 2020 Jun 14;56(47):6328-6331. doi: 10.1039/d0cc02498h

Weber EMM, Kress T, Abergel D, Sewsurn S, Azais T, Kurzbach D. Assessing the Onset of Calcium Phosphate Nucleation by Hyperpolarized Real-Time NMR. Analytical Chemistry. 2020 Jun 2;92(11):7666-7673. doi: 10.1021/acs.analchem.0c00516

Szekely O, Olsen GL, Novakovic M, Rosenzweig R, Frydman L. Assessing Site-Specific Enhancements Imparted by Hyperpolarized Water in Folded and Unfolded Proteins by 2D HMQC NMR. Journal of the American Chemical Society. 2020 Mai 20;142(20):9267-9284. doi: 10.1021/jacs.0c00807

Ozcan A, Sahin D, Impellizzieri D, Nguyen TT, Hafner J, Yawalkar N et al. Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis. Journal of Investigative Dermatology. 2020 Mai;140(5):1003-1014.e8. e8. doi: 10.1016/j.jid.2019.09.018

Toprakcioglu Z, Hakala TA, Levin A, Becker CFW, Bernandes GJL, Knowles TPJ. Erratum: Multi-scale microporous silica microcapsules from gas-in water-in oil emulsions (Soft Matter (2020) DOI: 10.1039/c9sm02274k). Soft Matter. 2020 Apr 14;16(14):3586-3586. doi: 10.1039/d0sm90059a

Publikationen Institut für Biologische Chemie (gegr. 2011)