Publikationen

Plöchl K , Böttcher T. A novel class of small-molecule inhibitors targeting bacteriophage infection. RSC Chemical Biology. 2026 Jan;7(1):31-37. doi: 10.1039/d5cb00120j

Jancheva M , Nguyen THN , Anderl F, Joge S, Neubauer J, Rominger-Baumann C et al. A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress. Chemical Science. 2026;17(2):1151-1157 . doi: 10.1039/d5sc04923g

Laborde Q, Peigneur S, Jacobsson E, Göransson U, Tytgat J, Andersson HS. Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding to Target Receptors. Journal of Natural Products. 2025 Dez 17. Epub 2025 Dez 17. doi: 10.1021/acs.jnatprod.5c01177

Zachrdla M , Turhan E, Bučková M, Hänsel-Hertsch R, Trantírek L, Kurzbach D. Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA. Journal of the American Chemical Society. 2025 Dez 17;147(50):46563-46572. doi: 10.1021/jacs.5c17542

Venkadakrishnan J, Bhat A, Jadhav KB, Dhar A. Angiotensin II-induced fibrosis is mediated by activation of FGFR1 pathway in renal epithelial cells: Attenuation by chimeric peptide. European Journal of Pharmacology. 2025 Dez 15;1009:178390. doi: 10.1016/j.ejphar.2025.178390

Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J et al. Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. Journal of Medicinal Chemistry. 2025 Dez 11;68(23):24924-24934. Epub 2025 Nov 19. doi: 10.1021/acs.jmedchem.5c01756

Brandis D, Obrist D, Haßler MFT , Kurzbach D. Biomimetic, Peptide-guided Silica Formation by Real-time NMR of Elastin-like and R5 Fusion Peptides – Bimodal Peptide Aggregation Drives Dual-pathway Silicification Mechanisms. Journal of Molecular Biology. 2025 Dez 1;437(23):169303. doi: 10.1016/j.jmb.2025.169303

Sirivibulkovit K, Voelkle J , Windisch DJ , Muttenthaler M , Lieberzeit PA, Saetear P. Electrochemical dengue sensor based on NS1 epitope-imprinted polymers. Biosensors and Bioelectronics. 2025 Dez 1;289:117915. doi: 10.1016/j.bios.2025.117915

Cinquina V, Tretiakov EO, Kalaba P, Alpár A, Calvigioni D, Piscitelli F et al. Astrocytes modulate neuronal development by S100A6 signaling. Nature Communications. 2025 Dez;16(1):9049. doi: 10.1038/s41467-025-64405-y

Garcia AB, Mourão CBR, Campos LA, Gómez-Lagunas F, Peigneur S, Carleer K et al. Exploring the unknown activity of the Huwentoxin-II spider toxin family: A screening of Ap1 toxins from Acanthoscurria paulensis venom. International Journal of Biological Macromolecules. 2025 Dez;334:149037. doi: 10.1016/j.ijbiomac.2025.149037

Fernandez-Carrasco I, Moral-Sanz J, Kurdyukov S, Monne ÈO, Hartmann LM, Magalhães Novais SC et al. The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions. Cell Death Discovery. 2025 Dez;11(1):538. doi: 10.1038/s41420-025-02817-x

Plöchl K , Böttcher T. The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles. Scientific Reports. 2025 Dez;15(1):44346. doi: 10.1038/s41598-025-27865-2

Faglia F, Thümmler JF, Pötzl C , Zachrdla M , Turhan E , Kurzbach D et al. The Core-Shell Conformational Space of Compartmentalized Single-Chain Nanoparticles by Paramagnetic and Hyperpolarized NMR Spectroscopy. Advanced Science. 2025 Nov 30;e10909. Epub 2025 Nov 30. doi: 10.1002/advs.202510909

Schlatzer T, Kriegesmann J, Bieber M, Becker CFW, Breinbauer R. Hydrophilic BIPHEPHOS Ligand for Pd-Mediated Cysteine Allylation of Peptides and Proteins in Water. Organic Letters. 2025 Nov 21;27(46):12813-12818. doi: 10.1021/acs.orglett.5c04112

Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M et al. Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization. Angewandte Chemie (International ed. in English). 2025 Nov 10;64(46):e202515180. e202515180. Epub 2025 Sep 26. doi: 10.1002/anie.202515180

Pascali G, Parmar A, Zanoni S, Arthur A, Hering A, Teakle N et al. Development and characterisation of novel oxytocin analogues for PET imaging. Communications Chemistry. 2025 Nov 5;8(1):328. doi: 10.1038/s42004-025-01649-1

Venkadakrishnan J, Vemana A, Ghatage T, Vesmaker K, Bhat A, Jadhav KB et al. Therapeutic Peptides Mitigates TLR4 Pathway Activation by Ang II in Renal and Vascular Smooth Muscle Cells. Journal of biochemical and molecular toxicology. 2025 Nov;39(11):e70579. doi: 10.1002/jbt.70579

Denisov SS, Bialek EL, Beretta F, Smagurauskaite G, Ippel H, Fijlstra E et al. Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display. ACS Chemical Biology. 2025 Okt 28. Epub 2025 Okt 28. doi: 10.1021/acschembio.5c00726

Turhan E , Pötzl C, Brandis D, Faglia F , Zachrdla M , Kurzbach D. Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins Without Resolution Loss: Access to Short-Lived Intermediates. Chemistry - A European Journal. 2025 Okt 22;31(59):e02067. Epub 2025. doi: 10.1002/chem.202502067

Brandis D, Turhan E , Zachrdla M , Kurzbach D. Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces. Journal of the American Chemical Society. 2025 Okt 8;147(40):36920-36927. doi: 10.1021/jacs.5c15053

Pötzl C , Turhan E, Gervais C, Azaïs T, Kurzbach D. Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters. Analytical Chemistry. 2025 Sep. Epub 2025 Sep. doi: 10.1021/acs.analchem.5c02945

Gattringer J, Hasinger S, Weidmann A, Walczewska-Szewc K, Jadhav KB, Zrzavy T et al. Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching. Journal of Medicinal Chemistry. 2025 Aug 28;68(16):17202-17220. doi: 10.1021/acs.jmedchem.5c00677

Tocino-Márquez I, Zehl M, Séneca Cardoso Da Silva J , Pjevac P , Felkl M , Becker CFW et al. The bacterial community of the freshwater bryozoan Cristatella Mucedo and its secondary metabolites production potential. Scientific Reports. 2025 Aug 26;15(1):31456. doi: 10.1038/s41598-025-17084-0

Weissinger H , Urschbach M , Ferrari L , Martens S , Becker CFW. Photocatalytic Diselenide Contraction as a Tool for Site-Selective Isosteric Ubiquitylation. Journal of Peptide Science. 2025 Aug;31(8):e70037. doi: 10.1002/psc.70037

Rasoulimehrabani H, Riva A, Inan D, Hodžić A, Hausmann B, Nikolov G et al. Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting. Gut microbes. 2025 Jun 27;17(1):2525482. doi: 10.1080/19490976.2025.2525482

Kerčmar J, Murko N, Križančić Bombek L, Paradiž Leitgeb E, Pfabe J, Postić S et al. Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses. eLife. 2025 Mai 30. doi: 10.7554/elife.106679.1

Urschbach M, Huhmann S, Appel D, Ferrari L, Vogl D, Martens S et al. Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry. Angewandte Chemie - International Edition. 2025 Mai 19;64(21):e202502638. Epub 2025 Mär 15. doi: 10.1002/anie.202502638

Ostrovitsa N, Williams C, Raabe K, McLean JT, Muttenthaler M, Scanlan EM. An Efficient Thiol-ene Mediated Protocol for Thiolated Peptide Synthesis and On-Resin Diversification. Chemistry: A European Journal. 2025 Mai 15;31(36):e202501372. Epub 2025 Mai 15. doi: 10.1002/chem.202501372

Brandis D, Mollica G, Kurzbach D. R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules. Journal of Physical Chemistry Letters. 2025 Mai 1;16(17):4326-4335. doi: 10.1021/acs.jpclett.5c00144

Makarov SE, Vujisić L, Raspotnig G, Antić D, Anderl F, Krstić G et al. Scenting Ketones in the Defense Glands of Two Julids From the Caucasus (Arthropoda, Myriapoda, Diplopoda, Julida). Journal of Chemical Ecology. 2025 Apr 29;51(3):50. 50. doi: 10.1007/s10886-025-01603-4

Savchenko V, Yu XA, Polz MF , Böttcher T. Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers. ACS Chemical Biology. 2025 Apr 18;20(4):960-966. Epub 2025. doi: 10.1021/acschembio.5c00046

Mix AK, Nguyen THN, Schuhmacher T, Szamosvári D, Muenzner P, Haas P et al. A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system. Nature Microbiology. 2025 Apr;10(4):939-957. 35. doi: 10.1038/s41564-025-01968-y

Elmaci DN, Hopping G, Hoffmann W, Muttenthaler M, Stein M. The structural integrity of human TFF1 under reducing conditions. Redox biology. 2025 Apr;81:103534. doi: 10.1016/j.redox.2025.103534

Burger I, Schmal M, Peikert K, Fourtis L, Suster C, Stanetty C et al. Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. Biotechnology for biofuels and bioproducts. 2025 Mär 11;18(1):32. doi: 10.1186/s13068-025-02628-3

Brandis D, Kaderávek P, Kurzbach D. The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies by ¹³C‑Direct Detected NMR Spectroscopy. Analytical Chemistry. 2025 Feb 25;97(7):3937-3944. doi: 10.1021/acs.analchem.4c05163

Kratzwald S, Schwarz TC, Ledolter K, Hlavac M, Felkl M , Becker CFW et al. Synthesis of a ¹³C/²H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy. ChemBioChem. 2025 Jan 2;26(1):e202400663. Epub 2024. doi: 10.1002/cbic.202400663

Sokolova N, Denisov SS, Hackl T, Haslinger K. Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi. Angewandte Chemie - International Edition. 2025;e202514786. doi: 10.1002/anie.202514786

Kremsmayr T, Schober G, Kaltenböck M, Hoare BL, Brierley SM, Muttenthaler M. Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie - International Edition. 2024 Dez 20;63(52):e202415333. Epub 2024 Nov. doi: 10.1002/anie.202415333

Baldensperger T , Preissler M , Becker CFW. Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases. RSC Chemical Biology. 2024 Dez 19;6(2):129-149. Epub 2024. doi: 10.1039/d4cb00221k

Riedl S, Bilgen E, Agam G, Hirvonen V, Jussupow A, Tippl F et al. Evolution of the conformational dynamics of the molecular chaperone Hsp90. Nature Communications. 2024 Dez;15(1):8627. doi: 10.1038/s41467-024-52995-y

Turhan E, Minaei M, Narwal P, Meier B, Kouřil K, Kurzbach D. Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization. Communications Chemistry. 2024 Dez;7(1):210. doi: 10.1038/s42004-024-01300-5

Pereira FC, Ge X, Kristensen JM, Kirkegaard RH, Maritsch K, Szamosvári D et al. The Parkinson's disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration. Nature Microbiology. 2024 Dez;9(12):3165–3183. Epub 2024 Nov 21. doi: 10.1038/s41564-024-01853-0

Baldensperger T, Jung T, Heinze T, Schwerdtle T, Höhn A, Grune T. The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death. Free Radical Biology and Medicine. 2024 Nov 20;225:871-880. doi: 10.1016/j.freeradbiomed.2024.10.311

Jandl B, Dighe S, Baumgartner M, Makristathis A, Gasche C, Muttenthaler M. Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies. Gastroenterology. 2024 Nov;167(6):1098-1112.e5. doi: 10.1053/j.gastro.2024.04.032

Turhan E, Goldberga I, Pötzl C, Keil W, Guigner JM, Haßler MFT et al. Branched Polymeric Prenucleation Assemblies Initiate Calcium Phosphate Precipitation. Journal of the American Chemical Society. 2024 Sep 18;146(37):25614-25624. Epub 2024. doi: 10.1021/jacs.4c07325

Jandl B, Dighe S, Gasche C, Makristathis A, Muttenthaler M. Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews. 2024 Sep 12;37(3):e00133-23. Epub 2024 Jul 12. doi: 10.1128/cmr.00133-23

Jandl B, Zheng R, Muttenthaler M, Baell J. Novel Diacyl-hydrazide Compounds as Potential Therapeutics for Visceral Leishmaniasis. ACS Omega. 2024 Sep 3;9(35):37170-37182. Epub 2024 Aug 22. doi: 10.1021/acsomega.4c04517

Steuer J, Sinn M, Eble F, Rütschlin S, Böttcher T, Hartig JS et al. Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch. NAR Genomics and Bioinformatics. 2024 Sep 1;6(3):lqae132. doi: 10.1093/nargab/lqae132

Savchenko V, Jaegers M, Rasche R, Herrmann E, König S, Kümmel D et al. Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis. Cell Reports Physical Science. 2024 Aug 21;5(8):102100. Epub 2024 Jul 10. doi: 10.1016/j.xcrp.2024.102100

Kozak F, Brandis D, Pötzl C, Epasto LM, Reichinger D, Obrist D et al. An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation. Advanced science. 2024 Aug 14;11(30):2401239. Epub 2024. doi: 10.1002/advs.202401239

Publikationen Institut für Biologische Chemie (gegr. 2011)