Publications Institut of Biological Chemistry (founded 2011)

Ghatage T, Singh S, Mandal K, Jadhav KB, Dhar A. Activation of Mas and pGCA receptor pathways protects renal epithelial cell damage against oxidative-stress-induced injury. Peptides. 2023 Apr;162. 170959. https://doi.org/10.1016/j.peptides.2023.170959

Strobl J, Kozak F, Kamalov M, Reichinger D, Kurzbach D , Becker CFW. Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology. Advanced Materials. 2023 Mar 16;35(11). 2207586. https://doi.org/10.1002/adma.202207586

Negroni M, Kurzbach D. Missing Pieces in Structure Puzzles: How Hyperpolarized NMR Spectroscopy Can Complement Structural Biology and Biochemistry. ChemBioChem. 2023 Mar 14;24(6). e202200703. https://doi.org/10.1002/cbic.202200703

Lubec J, Hussein AM, Kalaba P, Feyissa DD, Arias-Sandoval E, Cybulska-Klosowicz A et al. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. 2023 Mar 3;13(3). 467. https://doi.org/10.3390/biom13030467

Reichinger D, Reithofer M, Hohagen M, Drinic M, Tobias J, Wiedermann U et al. A Biomimetic, Silaffin R5-Based Antigen Delivery Platform. Pharmaceutics. 2023 Jan;15(1). 121. https://doi.org/10.3390/pharmaceutics15010121

Kriegesmann J, Schlatzer T, Che K, Altdorf C, Huhmann S, Kählig H et al. Constraining and Modifying Peptides Using Pd-Mediated Cysteine Allylation. ChemBioChem. 2023. https://doi.org/10.1002/cbic.202300098

Dowman LJ, Kulkarni SS, Alegre-Requena J, Giltrap AM, Norman AR, Sharma A et al. Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Nature Communications. 2022 Nov 12;13(1). 6885. https://doi.org/10.1038/s41467-022-34530-z

Negroni M, Turhan E, Kress T, Ceillier M, Jannin S, Kurzbach D. Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging. Journal of the American Chemical Society. 2022 Nov;144(45):20680-20686. https://doi.org/10.1021/jacs.2c07960

Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA , Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. https://doi.org/10.1021/acschembio.2c00626

Kerul L, Schrems M, Schmid A, Meli R, Becker CFW, Bello C. Semisynthesis of Homogeneous, Active Granulocyte Colony-Stimulating Factor Glycoforms. Angewandte Chemie (International Edition). 2022 Sep 26;61(39):1-10. e202206116. https://doi.org/10.1002/anie.202206116

Epasto LM, Honegger P, Che K, Kozak F , Jörg F , Schröder C et al. Nuclear Overhauser spectroscopy in hyperpolarized water - chemical vs. magnetic exchange. Chemical Communications. 2022 Sep;58(83):11661-11664. https://doi.org/10.1039/d2cc03735a

Epasto LM, Che K, Kozak F, Selimovic A, Kaderavek P, Kurzbach D. Toward protein NMR at physiological concentrations by hyperpolarized water-Finding and mapping uncharted conformational spaces. Science Advances. 2022 Aug 5;8(31). eabq5179. https://doi.org/10.1126/sciadv.abq5179

Hering A, Emidio NB, Muttenthaler M. Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. Chemical Communications. 2022 Jul 26;58(65):9100-9103. https://doi.org/10.1039/d2cc03752a

Kouhnavardi S, Ecevitoglu A, Dragacevic V, Sanna F, Arias-Sandoval E, Kalaba P et al. A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions. Biomolecules. 2022 Jul;12(7). 881. https://doi.org/10.3390/biom12070881

Liu H, Muttenthaler M. High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer. Biomedicines. 2022 Jul;10(7). 1595. https://doi.org/10.3390/biomedicines10071595

Hering A, Jieu B, Jones A, Muttenthaler M. Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry. Frontiers in Chemistry. 2022 Jun 9;10. 889154. https://doi.org/10.3389/fchem.2022.889154

Negroni M, Guarin D, Che K, Epasto LM , Turhan E, Selimovic A et al. Inversion of Hyperpolarized ¹³C NMR Signals through Cross-Correlated Cross-Relaxation in Dissolution DNP Experiments. Journal of Physical Chemistry B. 2022 Jun 8;126(24):4599-4610. https://doi.org/10.1021/acs.jpcb.2c03375

Kulkarni SS, Watson EE, Maxwell JWC, Niederacher G, Johansen-Leete J, Huhmann S et al. Expressed Protein Selenoester Ligation. Angewandte Chemie (International Edition). 2022 May 9;61(20). e202200163. https://doi.org/10.1002/anie.202200163

Hilty C, Kurzbach D, Frydman L. Hyperpolarized water as universal sensitivity booster in biomolecular NMR. Nature Protocols. 2022 May;17(7):1621-1657. https://doi.org/10.1038/s41596-022-00693-8

Kremsmayr T, Aljnabi A, Blanco-Canosa JB, Tran HNT, Emidio NB, Muttenthaler M. On the Utility of Chemical Strategies to Improve Peptide Gut Stability. Journal of Medicinal Chemistry. 2022 Apr 28;65(8):6191-6206. https://doi.org/10.1021/acs.jmedchem.2c00094

Hanna C, Kriegesmann J, Dowman L, Becker C, Payne RJ. Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angewandte Chemie (International Edition). 2022 Apr 4;61(15). e202111266. https://doi.org/10.1002/anie.202111266

Klein K, Garkov D, Rütschlin S, Böttcher T, Schreiber F. QSDB—a graphical Quorum Sensing Database. Database: The Journal of Biological Databases and Curation. 2021 Nov 26;2021. baab058. https://doi.org/10.1093/database/baab058

Böttcher T, Nguyen THN, Szamosvari D. Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives. ARKIVOC. 2021 Nov 12;2021(9):218-239. https://doi.org/10.24820/ark.5550190.p011.547

Muratspahic E, Retzl B, Dürrauer L , Freissmuth M , Becker CFW, Gruber CW. Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor. Frontiers in Pharmacology. 2021 Oct 22;12. 773029. https://doi.org/10.3389/fphar.2021.773029

Negroni M, Kurzbach D. Residue-resolved monitoring of protein hyperpolarization at sub-second time resolution. Communications Chemistry. 2021 Oct 22;4(1). 147. https://doi.org/10.1038/s42004-021-00587-y

Bialas F, Reichinger D, Becker CFW. Biomimetic and biopolymer-based enzyme encapsulation. Enzyme and microbial Technology. 2021 Oct;150. 109864. https://doi.org/10.1016/j.enzmictec.2021.109864

Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P et al. Mucosal Biofilms Are an Endoscopic Feature of Irritable Bowel Syndrome and Ulcerative Colitis. Gastroenterology. 2021 Oct;161(4):1245-1256. https://doi.org/10.1053/j.gastro.2021.06.024

Bialas F, Becker CFW. Biomimetic Silica Encapsulation of Lipid Nanodiscs and β-Sheet-Stabilized Diacylglycerol Kinase. Bioconjugate Chemistry. 2021 Aug 18;32(8):1742-1752. https://doi.org/10.1021/acs.bioconjchem.1c00260

Vogl DP, Conibear AC, Becker CFW. Segmental and site-specific isotope labelling strategies for structural analysis of posttranslationally modified proteins. RSC Chemical Biology. 2021 Aug;2(5):1441-1461. https://doi.org/10.1039/d1cb00045d

Epasto LM, Georges T, Selimovic A, Guigner J-M, Azais T, Kurzbach D. Formation and Evolution of Nanoscale Calcium Phosphate Precursors under Biomimetic Conditions. Analytical Chemistry. 2021 Jul 27;93(29):10204-10211. https://doi.org/10.1021/acs.analchem.1c01561

Emidio NB, Meli R, Tran HNT, Baik H, Morisset-Lopez S, Elliott AG et al. Chemical Synthesis of TFF3 Reveals Novel Mechanistic Insights and a Gut-Stable Metabolite. Journal of Medicinal Chemistry. 2021 Jul 18;64(13):9484-9495. https://doi.org/10.1021/acs.jmedchem.1c00767

Emidio NB, Tran HNT, Andersson A, Dawson PE, Albericio F, Vetter I et al. Improving the Gastrointestinal Stability of Linaclotide. Journal of Medicinal Chemistry. 2021 Jun 24;64(12):8384-8390. https://doi.org/10.1021/acs.jmedchem.1c00380

Jancheva M, Boettcher T. A Metabolite of Pseudomonas Triggers Prophage-Selective Lysogenic to Lytic Conversion in Staphylococcus aureus. Journal of the American Chemical Society. 2021 Jun 9;143(22):8344-8351. https://doi.org/10.1021/jacs.1c01275

Kress T, Che K, Epasto LM , Kozak F, Negroni M, Olsen GL et al. A novel sample handling system for dissolution dynamic nuclear polarization experiments. Magnetic Resonance. 2021 Jun 4;2(1):387–394. https://doi.org/10.5194/mr-2-387-2021

Prothiwa M, Filz V, Oehler S, Boettcher T. Inhibiting quinolone biosynthesis of Burkholderia. Chemical Science. 2021 May 28;12(20):6908-6912. https://doi.org/10.1039/d0sc06167k

Ray RM, Hansen AH, Taskova M, Jandl B, Hansen J, Soemardy C et al. Enhanced target cell specificity and uptake of lipid nanoparticles using RNA aptamers and peptides. Beilstein Journal of Organic Chemistry. 2021 Apr 26;17:891-907. https://doi.org/10.3762/bjoc.17.75

Muttenthaler M, King GF, Adams DJ, Alewood PF. Trends in peptide drug discovery. Nature Reviews Drug Discovery. 2021 Apr 1;20(4):309-325. https://doi.org/10.1038/s41573-020-00135-8

Niederacher G, Urwin D, Dijkwel Y, Tremethick DJ, Rosengren KJ, Becker CFW et al. Site-specific modification and segmental isotope labelling of HMGN1 reveals long-range conformational perturbations caused by posttranslational modifications. RSC Chemical Biology. 2021 Apr;2(2):537-550. https://doi.org/10.1039/d0cb00175a

Dekan Z, Kremsmayr T, Keov P, Godin M, Teakle N, Durrauer L et al. Nature-inspired dimerization as a strategy to modulate neuropeptide pharmacology exemplified with vasopressin and oxytocin. Chemical Science. 2021 Mar 21;12(11):4057-4062. https://doi.org/10.1039/d0sc05501h

Penalver L, Schmid P, Szamosvari D, Schildknecht S, Globisch C, Sawade K et al. A Ligand Selection Strategy Identifies Chemical Probes Targeting the Proteases of SARS-CoV-2. Angewandte Chemie (International Edition). 2021 Mar 15;60(12):6799-6806. https://doi.org/10.1002/anie.202016113

Balana AT, Levine PM, Craven TW, Mukherjee S, Pedowitz NJ, Moon SP et al. O-GlcNAc modification of small heat shock proteins enhances their anti-amyloid chaperone activity. Nature Chemistry. 2021 Mar 15;13:441–450. https://doi.org/10.1038/s41557-021-00648-8

Fruehwirth S, Egger S, Kurzbach D , Windisch J , Jirsa F, Flecker T et al. Ingredient-Dependent Extent of Lipid Oxidation in Margarine. Antioxidants. 2021 Jan 13;10(1):1-17. 105. https://doi.org/10.3390/antiox10010105

Hackl S, Ng XW, Lu D, Wohland T, Becker CFW. Cytoskeleton-dependent clustering of membrane-bound prion protein on the cell surface. Journal of Biological Chemistry. 2021 Jan 1;296. 100359. https://doi.org/10.1016/j.jbc.2021.100359

Che K, Muttenthaler M , Kurzbach D. Conformational selection of vasopressin upon V_1a receptor binding. Computational and Structural Biotechnology Journal. 2021 Jan;19:5826-5833. https://doi.org/10.1016/j.csbj.2021.10.024

Kozak F , Kurzbach D. How to assess the structural dynamics of transcription factors by integrating sparse NMR and EPR constraints with molecular dynamics simulations. Computational and Structural Biotechnology Journal. 2021;19:2097-2105. https://doi.org/10.1016/j.csbj.2021.04.020

Kalra J, Dasari D, Bhat A, Mangali S, Goyal SG, Jadhav KB et al. PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats. Life Sciences. 2020 Dec 1;262. 118436. https://doi.org/10.1016/j.lfs.2020.118436

Dey A, Charrier B, Martineau E, Deborde C, Gandriau E, Moing A et al. Hyperpolarized NMR Metabolomics at Natural 13C Abundance. Analytical Chemistry. 2020 Nov 17;92(22):14867-14871. https://doi.org/10.1021/acs.analchem.0c03510

Peschel A, Cardoso FC, Walker AA, Durek T, Stone MRL, Emidio NB et al. Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency. Journal of Medicinal Chemistry. 2020 Nov 12;63(21):12773-12785. https://doi.org/10.1021/acs.jmedchem.0c01107

Sicoli G, Kress T, Vezin H, Ledolter K, Kurzbach D. A Switch between Two Intrinsically Disordered Conformational Ensembles Modulates the Active Site of a Basic-Helix-Loop-Helix Transcription Factor. The Journal of Physical Chemistry Letters. 2020 Nov 5;11(21):8944-8951. https://doi.org/10.1021/acs.jpclett.0c02242

Mendel HC, Kaas Q, Muttenthaler M. Neuropeptide signalling systems - An underexplored target for venom drug discovery. Biochemical Pharmacology. 2020 Nov;181. 114129. https://doi.org/10.1016/j.bcp.2020.114129