Publications Institut of Biological Chemistry (founded 2011)
Hellinger R, Schwarz P, Dieringer J, Ebermann C, Jadhav KB, Muttenthaler M et al. Tropical psychotria plants are a rich source for peptide inhibitors of human prolyl oligopeptidase. Natural Products and Bioprospecting. 2026 Dec;16(1):54. doi: 10.1007/s13659-026-00598-z
Weiser M, Frischauf A, Stoger B, Turhan E, Kurzbach D, Bica-Schroder K. Visible-Light-Initiated, Nickel-Catalyzed Aminocarbonylation of Alkynyl Iodides to 2-Ynamides. Advanced Synthesis & Catalysis. 2026 Sept 23;368(19):e70758. doi: 10.1002/adsc.70758
Kormout F, Turhan E, Soussi-Therond M, Zachrdla M, Kurzbach D. Following Transient Conformational Adaptations during Peptide-Guided Calcium Phosphate Biomineralization with Hyperpolarized NMR. JACS Au. 2026 Sept. Epub 2026 Sept. doi: 10.1021/jacsau.6c01076
Kowalewski M, Tomašových A, Nawrot R, Scarponi D, Zuschin M, Albano PG et al. Sediment accumulation rate predicts the temporal resolution of marine fossil assemblages. Proceedings of the National Academy of Sciences of the United States of America. 2026 Aug 4;123(31):e2615368123. doi: 10.1073/pnas.2615368123
Zachrdla M, Turhan E, Bučková M, Trantírek L, Kurzbach D. Unmasking DNA Resonances by Suppression of Hyperpolarized Water. Journal of the American Chemical Society. 2026 Jul;148(30):32297-32306. doi: 10.1021/jacs.6c07731
Kalaba P, Böhm MP, D̵ikić F, Tomašević N, Drdla-Schutting R, Hasinger S et al. Development and Biological Characterization of Fluorescent Dynorphins for the Visualization of Kappa Opioid Receptors. Journal of Medicinal Chemistry. 2026 Jun 25;69(12):14098-14113. Epub 2026 Jun 5. doi: 10.1021/acs.jmedchem.5c03072
Baldensperger T, Hampel A, Becker CFW. Effects of Site-Specific Glycation on α-Synuclein. ACS Chemical Biology. 2026 Jun 18. Epub 2026 Jun 18. doi: 10.1021/acschembio.6c00322
Williams C, Raabe K, Tully D, Windisch D, O'Brien J, Trujillo C et al. Synthesis of Macrocyclic Peptides via Photochemical Radical Thiol-yne Reaction. Journal of the American Chemical Society. 2026 Jun 10. Epub 2026 Jun 10. doi: 10.1021/jacs.6c08113
Raabe K, Kalaba P, Yong XLH, Crudeli G, Melzer S, Keimpema E et al. Photocaged Oxytocin and Vasopressin Probes to Decipher Neuropeptide Signalling With High Spatiotemporal Resolution. Angewandte Chemie (International ed. in English). 2026 May 25;65(22):e13373. Epub 2026 Apr 13. doi: 10.1002/anie.202513373
Iriarte-Mesa C, Juère E, Bileck A, Kremsmayr T, Goodson ML, Ehrlich A et al. Mesoporous Silica Nanoparticles-Based Formulations for Enhanced Oral Delivery of Peptide Drugs: A Case Study on Insulin. Small. 2026 Apr 27;22(24):e13347. doi: 10.1002/smll.202513347
Menezes C, Thakur N, Carleer K, Peigneur S, Tytgat J. Identification and functional characterization of a Nav-targeting peptide NavTx-Bg1 from sea anemone Bunodosoma goanense (Vennam & den Hartog, 1993) transcriptome. Toxicon. 2026 Apr 1;273:109016. doi: 10.1016/j.toxicon.2026.109016
Epasto LM, Khalil M, Sicoli G, Kurzbach D. Domain-Specific Electron Paramagnetic Resonance Spectroscopy to Monitor Facilitated Dissociation of a DNA-Transcription Factor Complex. Chemistry-Methods. 2026 Mar;6(3):e202500141. doi: 10.1002/cmtd.202500141
Plöchl K, Böttcher T. A novel class of small-molecule inhibitors targeting bacteriophage infection. RSC Chemical Biology. 2026 Jan 1;7(1):31-37. doi: 10.1039/d5cb00120j
Sutro JL, Anderl F, Haf-Moths P, Fürstner A. 1,3-Brook Rearrangement of α-Silyl Allylic Alcohols: Copper-Catalyzed Enantiospecific Formation of Allenes and Copper-Mediated ipso-Substitution Reactions Affording Trisubstituted Alkenes. Angewandte Chemie - International Edition. 2026. Epub 2026. doi: 10.1002/anie.5791239
Jancheva M, Nguyen THN, Anderl F, Joge S, Neubauer J, Rominger-Baumann C et al. A phage-selective trigger hints at an SOS-independent mechanism of prophage induction by oxidative stress. Chemical Science. 2026;17(2):1151-1157 . doi: 10.1039/d5sc04923g
Plazzo AP, Filz V, Prothiwa M, Lambrecht R, Delgado ME, Fleming JR et al. Microbiome-host communication via vaccenic acid modulates LRH-1/NR5A2 activity and ameliorates metabolic liver disease. EMBO Molecular Medicine. 2026. Epub 2026. doi: 10.1038/s44321-026-00516-3
Vogl DP, Migotti M, Konrat R, Conibear AC, Becker CFW. Modifications of Lysine Residues 294 and 311 Within the Microtubule-Binding Region Alter Tau Aggregation and Tubulin Binding Equilibria. Angewandte Chemie - International Edition. 2026. Epub 2026. doi: 10.1002/anie.1521091
Laborde Q, Peigneur S, Jacobsson E, Göransson U, Tytgat J, Andersson HS. Alanine Mutagenesis Identifies Specific Amino Acids of Nemertide Alpha-1 Activity and Its Binding to Target Receptors. Journal of Natural Products. 2025 Dec 17;89(1):95-103. Epub 2025 Dec 17. doi: 10.1021/acs.jnatprod.5c01177
Zachrdla M, Turhan E, Bučková M, Hänsel-Hertsch R, Trantírek L, Kurzbach D. Hyperpolarized NMR Reveals Low-Populated Folding Intermediates in DNA. Journal of the American Chemical Society. 2025 Dec 17;147(50):46563-46572. doi: 10.1021/jacs.5c17542
Venkadakrishnan J, Bhat A, Jadhav KB, Dhar A. Angiotensin II-induced fibrosis is mediated by activation of FGFR1 pathway in renal epithelial cells: Attenuation by chimeric peptide. European Journal of Pharmacology. 2025 Dec 15;1009:178390. doi: 10.1016/j.ejphar.2025.178390
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J et al. Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. Journal of Medicinal Chemistry. 2025 Dec 11;68(23):24924-24934. Epub 2025 Nov 19. doi: 10.1021/acs.jmedchem.5c01756
Brandis D, Obrist D, Haßler MFT, Kurzbach D. Biomimetic, Peptide-guided Silica Formation by Real-time NMR of Elastin-like and R5 Fusion Peptides – Bimodal Peptide Aggregation Drives Dual-pathway Silicification Mechanisms. Journal of Molecular Biology. 2025 Dec 1;437(23):169303. doi: 10.1016/j.jmb.2025.169303
Sirivibulkovit K, Voelkle J, Windisch DJ, Muttenthaler M, Lieberzeit PA, Saetear P. Electrochemical dengue sensor based on NS1 epitope-imprinted polymers. Biosensors and Bioelectronics. 2025 Dec 1;289:117915. doi: 10.1016/j.bios.2025.117915
Cinquina V, Tretiakov EO, Kalaba P, Alpár A, Calvigioni D, Piscitelli F et al. Astrocytes modulate neuronal development by S100A6 signaling. Nature Communications. 2025 Dec;16(1):9049. doi: 10.1038/s41467-025-64405-y
Garcia AB, Mourão CBR, Campos LA, Gómez-Lagunas F, Peigneur S, Carleer K et al. Exploring the unknown activity of the Huwentoxin-II spider toxin family: A screening of Ap1 toxins from Acanthoscurria paulensis venom. International Journal of Biological Macromolecules. 2025 Dec;334:149037. doi: 10.1016/j.ijbiomac.2025.149037
Fernandez-Carrasco I, Moral-Sanz J, Kurdyukov S, Monne ÈO, Hartmann LM, Magalhães Novais SC et al. The cytotoxicity of gomesin peptides is mediated by the glycosphingolipid pathway and lipid-cholesterol interactions. Cell Death Discovery. 2025 Dec;11(1):538. doi: 10.1038/s41420-025-02817-x
Plöchl K, Böttcher T. The solute-binding proteins DppA1–5 of Pseudomonas aeruginosa have distinct substrate profiles. Scientific Reports. 2025 Dec;15(1):44346. doi: 10.1038/s41598-025-27865-2
Faglia F, Thümmler JF, Pötzl C, Zachrdla M, Turhan E, Kurzbach D et al. The Core-Shell Conformational Space of Compartmentalized Single-Chain Nanoparticles by Paramagnetic and Hyperpolarized NMR Spectroscopy. Advanced Science. 2025 Nov 30;13(9):e10909. Epub 2025 Nov 30. doi: 10.1002/advs.202510909
Schlatzer T, Kriegesmann J, Bieber M, Becker CFW, Breinbauer R. Hydrophilic BIPHEPHOS Ligand for Pd-Mediated Cysteine Allylation of Peptides and Proteins in Water. Organic Letters. 2025 Nov 21;27(46):12813-12818. doi: 10.1021/acs.orglett.5c04112
Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M et al. Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization. Angewandte Chemie (International ed. in English). 2025 Nov 10;64(46):e202515180. Epub 2025 Sept 26. doi: 10.1002/anie.202515180
Pascali G, Parmar A, Zanoni S, Arthur A, Hering A, Teakle N et al. Development and characterisation of novel oxytocin analogues for PET imaging. Communications Chemistry. 2025 Nov 5;8(1):328. doi: 10.1038/s42004-025-01649-1
Venkadakrishnan J, Vemana A, Ghatage T, Vesmaker K, Bhat A, Jadhav KB et al. Therapeutic Peptides Mitigates TLR4 Pathway Activation by Ang II in Renal and Vascular Smooth Muscle Cells. Journal of biochemical and molecular toxicology. 2025 Nov;39(11):e70579. doi: 10.1002/jbt.70579
Denisov SS, Bialek EL, Beretta F, Smagurauskaite G, Ippel H, Fijlstra E et al. Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display. ACS Chemical Biology. 2025 Oct 28;20(11):2798-2807. Epub 2025 Oct 28. doi: 10.1021/acschembio.5c00726
Turhan E, Pötzl C, Brandis D, Faglia F, Zachrdla M, Kurzbach D. Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins Without Resolution Loss: Access to Short-Lived Intermediates. Chemistry - A European Journal. 2025 Oct 22;31(59):e02067. Epub 2025. doi: 10.1002/chem.202502067
Brandis D, Turhan E, Zachrdla M, Kurzbach D. Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces. Journal of the American Chemical Society. 2025 Oct 8;147(40):36920-36927. doi: 10.1021/jacs.5c15053
Pötzl C, Turhan E, Gervais C, Azaïs T, Kurzbach D. Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters. Analytical Chemistry. 2025 Sept;97(37):20191-20200. Epub 2025 Sept. doi: 10.1021/acs.analchem.5c02945
Gattringer J, Hasinger S, Weidmann A, Walczewska-Szewc K, Jadhav KB, Zrzavy T et al. Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching. Journal of Medicinal Chemistry. 2025 Aug 28;68(16):17202-17220. doi: 10.1021/acs.jmedchem.5c00677
Tocino-Márquez I, Zehl M, Séneca Cardoso Da Silva J, Pjevac P, Felkl M, Becker CFW et al. The bacterial community of the freshwater bryozoan Cristatella Mucedo and its secondary metabolites production potential. Scientific Reports. 2025 Aug 26;15(1):31456. doi: 10.1038/s41598-025-17084-0
Weissinger H, Urschbach M, Ferrari L, Martens S, Becker CFW. Photocatalytic Diselenide Contraction as a Tool for Site-Selective Isosteric Ubiquitylation. Journal of Peptide Science. 2025 Aug;31(8):e70037. doi: 10.1002/psc.70037
Rasoulimehrabani H, Riva A, Inan D, Hodžić A, Hausmann B, Nikolov G et al. Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting. Gut microbes. 2025 Jun 27;17(1):2525482. doi: 10.1080/19490976.2025.2525482
Kerčmar J, Murko N, Križančić Bombek L, Paradiž Leitgeb E, Pfabe J, Postić S et al. Effects of Arginine Vasopressin on Islet Cells in Pancreatic Tissue Slices: Glucose-Dependent Modulation of IP3 Receptor-Specific Responses. eLife. 2025 May 30. doi: 10.7554/elife.106679.1
Urschbach M, Huhmann S, Appel D, Ferrari L, Vogl D, Martens S et al. Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry. Angewandte Chemie - International Edition. 2025 May 19;64(21):e202502638. Epub 2025 Mar 15. doi: 10.1002/anie.202502638
Ostrovitsa N, Williams C, Raabe K, McLean JT, Muttenthaler M, Scanlan EM. An Efficient Thiol-ene Mediated Protocol for Thiolated Peptide Synthesis and On-Resin Diversification. Chemistry: A European Journal. 2025 May 15;31(36):e202501372. Epub 2025 May 15. doi: 10.1002/chem.202501372
Brandis D, Mollica G, Kurzbach D. R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules. Journal of Physical Chemistry Letters. 2025 May 1;16(17):4326-4335. doi: 10.1021/acs.jpclett.5c00144
Makarov SE, Vujisić L, Raspotnig G, Antić D, Anderl F, Krstić G et al. Scenting Ketones in the Defense Glands of Two Julids From the Caucasus (Arthropoda, Myriapoda, Diplopoda, Julida). Journal of Chemical Ecology. 2025 Apr 29;51(3):50. doi: 10.1007/s10886-025-01603-4
Savchenko V, Yu XA, Polz MF, Böttcher T. Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers. ACS Chemical Biology. 2025 Apr 18;20(4):960-966. Epub 2025. doi: 10.1021/acschembio.5c00046
Mix AK, Nguyen THN, Schuhmacher T, Szamosvári D, Muenzner P, Haas P et al. A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system. Nature Microbiology. 2025 Apr;10(4):939-957. 35. doi: 10.1038/s41564-025-01968-y
Elmaci DN, Hopping G, Hoffmann W, Muttenthaler M, Stein M. The structural integrity of human TFF1 under reducing conditions. Redox biology. 2025 Apr;81:103534. doi: 10.1016/j.redox.2025.103534
Burger I, Schmal M, Peikert K, Fourtis L, Suster C, Stanetty C et al. Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. Biotechnology for biofuels and bioproducts. 2025 Mar 11;18(1):1-16. 32. doi: 10.1186/s13068-025-02628-3
Brandis D, Kaderávek P, Kurzbach D. The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies by 13C‑Direct Detected NMR Spectroscopy. Analytical Chemistry. 2025 Feb 25;97(7):3937-3944. doi: 10.1021/acs.analchem.4c05163