Publications Institut of Biological Chemistry (founded 2011)
Kozak F, Brandis D, Pötzl C, Epasto LM, Reichinger D, Obrist D et al. An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation. Advanced science. 2024 Aug 14;11(30):2401239. Epub 2024. doi: 10.1002/advs.202401239
Jandl B, Dighe S, Gasche C, Makristathis A, Muttenthaler M. Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews. 2024 Jul 12;e0013323. Epub 2024 Jul 12. doi: 10.1128/cmr.00133-23
Zachrdla M, Turhan E, Pötzl C, Sadet A, Vasos PR, Kurzbach D. Hyperpolarized nuclear Overhauser enhancement of alanine methyl groups by doubly relayed proton exchange. Journal of Magnetic Resonance. 2024 Jul;364:107727. doi: 10.1016/j.jmr.2024.107727
Epasto LM, Maimbourg T, Rosso A, Kurzbach D. Unified understanding of the breakdown of thermal mixing dynamic nuclear polarization: The role of temperature and radical concentration. Journal of Magnetic Resonance. 2024 May;362:107670. doi: 10.1016/j.jmr.2024.107670
Schmid A, Bello C, Becker CFW. Synthesis of N-Glycosylated Soluble Fas Ligand. Chemistry - A European Journal. 2024 Apr 25;30(24):e202400120. Epub 2024 Feb 16. doi: 10.1002/chem.202400120
Perisic M, Woolcock K, Hering A, Mendel H, Muttenthaler M. Oxytocin and vasopressin signaling in health and disease. Trends in Biochemical Sciences. 2024 Apr;49(4):361-377. doi: 10.1016/j.tibs.2024.01.010
Mengrelis K, Niederacher G, Prickler L, Kainz V, Weijler AM, Rudolph E et al. Coupling of a Major Allergen to the Surface of Immune Cells for Use in Prophylactic Cell Therapy for the Prevention of IgE-Mediated Allergy. Cells. 2024 Mar;13(5):446. doi: 10.3390/cells13050446
Vogl DP, Mateos B, Migotti M, Felkl M, Conibear AC, Konrat R et al. Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail. Bioorganic and Medicinal Chemistry. 2024 Feb 15;100:117617. doi: 10.1016/j.bmc.2024.117617
Kalaba P, Sanchez de la Rosa C, Möller A, Alewood PF, Muttenthaler M. Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers. Journal of Medicinal Chemistry. 2024 Feb 8;67(3):1625-1640. doi: 10.1021/acs.jmedchem.3c01089
Epasto LM, Pötzl C, Peterlik H, Khalil M, Saint-Pierre C, Gasparutto D et al. NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X. Protein Science. 2024 Jan;33(1):e4849. doi: 10.1002/pro.4849
Orgler E, Baumgartner M, Duller S, Kumptisch C, Hausmann B, Moser D et al. Archaea influence composition of endoscopically visible ileocolonic biofilms. Gut microbes. 2024;16(1):2359500. doi: 10.1080/19490976.2024.2359500
Savchenko V, Szamosvári D, Bao Y, Pignitter M, Böttcher T. Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response. Communications Chemistry. 2023 Dec;6(1):138. doi: 10.1038/s42004-023-00937-y
Dunajova Z, Mateu BP, Radler P, Lim K, Brandis D, Velicky P et al. Chiral and nematic phases of flexible active filaments. Nature Physics. 2023 Dec;19(12):1916-1926. doi: 10.1038/s41567-023-02218-w
Spreitzer I, Keife J, Strasser T, Kalaba P, Lubec J, Neuhaus W et al. Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution. International Journal of Molecular Sciences. 2023 Dec;24(23):16956. doi: 10.3390/ijms242316956
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL et al. Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor. Nature Communications. 2023 Nov 28;14(1):8064. doi: 10.1038/s41467-023-43718-w
Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M, König B. Photoswitchable Probes of Oxytocin and Vasopressin. Journal of Medicinal Chemistry. 2023 Nov 9;66(21):14853-14865. doi: 10.1021/acs.jmedchem.3c01415
Turhan E, Pötzl C, Keil W, Negroni M, Kouřil K, Meier B et al. Biphasic NMR of Hyperpolarized Suspensions-Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow. The Journal of Physical Chemistry Part C (Nanomaterials and Interfaces). 2023 Oct 5;127(39):19591-19598. doi: 10.1021/acs.jpcc.3c04198
Ückert AK, Rütschlin S, Gutbier S, Wörz NC, Miah MR, Martins AC et al. Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environment International. 2023 Oct 3;180:108229. doi: 10.1016/j.envint.2023.108229
Kalaba P, Pacher K, Neill PJ, Dragacevic V, Zehl M, Wackerlig J et al. Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry. Biomolecules. 2023 Sep;13(9):1415. doi: 10.3390/biom13091415
Schrems M, Kravchuk A, Niederacher G, Exler F, Bello C, Becker CFW. Light-Cleavable Auxiliary for Diselenide–Selenoester Ligations of Peptides and Proteins. Chemistry - A European Journal. 2023 Aug 15;29(46):e202301253. doi: 10.1002/chem.202301253
Kriegesmann J, Schlatzer T, Che K, Altdorf C, Huhmann S, Kählig H et al. Constraining and Modifying Peptides Using Pd-Mediated Cysteine Allylation. ChemBioChem. 2023 Jul 3;24(13):e202300098. doi: 10.1002/cbic.202300098
Mukherjee S, Vogl DP, Becker CFW. Site-Specific Glycation of Human Heat Shock Protein (Hsp27) Enhances Its Chaperone Activity. ACS Chemical Biology. 2023 Jul;18(8):1760-1771. doi: 10.1021/acschembio.3c00214
Bello C, Pranzini E, Piemontese E, Schrems M, Taddei ML, Giovannelli L et al. Chemoenzymatic Synthesis of Glycopeptides to Explore the Role of Mucin 1 Glycosylation in Cell Adhesion. ChemBioChem. 2023 Jun 15;24(12):e202200741. doi: 10.1002/cbic.202200741
Szamosvari D, Savchenko V, Badouin N, Böttcher T. Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif. Organic & Biomolecular Chemistry. 2023 May 30;21(25):5158-5163. doi: 10.1039/d3ob00710c
Ghatage T, Singh S, Mandal K, Jadhav KB, Dhar A. Activation of Mas and pGCA receptor pathways protects renal epithelial cell damage against oxidative-stress-induced injury. Peptides. 2023 Apr;162:170959. doi: 10.1016/j.peptides.2023.170959
Strobl J, Kozak F, Kamalov M, Reichinger D, Kurzbach D, Becker CFW. Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology. Advanced Materials. 2023 Mar 16;35(11):2207586. doi: 10.1002/adma.202207586
Grant PS, Cruz Meyrelles RJ, Gajsek O, Niederacher G, Maryasin B, Maulide N. Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes. Journal of the American Chemical Society. 2023 Mar 15;145(10):5855-5863. doi: 10.1021/jacs.2c13116
Negroni M, Kurzbach D. Missing Pieces in Structure Puzzles: How Hyperpolarized NMR Spectroscopy Can Complement Structural Biology and Biochemistry. ChemBioChem. 2023 Mar 14;24(6):e202200703. doi: 10.1002/cbic.202200703
Lubec J, Hussein AM, Kalaba P, Feyissa DD, Arias-Sandoval E, Cybulska-Klosowicz A et al. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. 2023 Mar 3;13(3):467. doi: 10.3390/biom13030467
Reichinger D, Reithofer M, Hohagen M, Drinic M, Tobias J, Wiedermann U et al. A Biomimetic, Silaffin R5-Based Antigen Delivery Platform. Pharmaceutics. 2023 Jan;15(1):121. doi: 10.3390/pharmaceutics15010121
Dowman LJ, Kulkarni SS, Alegre-Requena J, Giltrap AM, Norman AR, Sharma A et al. Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Nature Communications. 2022 Nov 12;13(1):6885. doi: 10.1038/s41467-022-34530-z
Negroni M, Turhan E, Kress T, Ceillier M, Jannin S, Kurzbach D. Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging. Journal of the American Chemical Society. 2022 Nov;144(45):20680-20686. doi: 10.1021/jacs.2c07960
Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. Epub 2022 Sep 26. doi: 10.1021/acschembio.2c00626
Kerul L, Schrems M, Schmid A, Meli R, Becker CFW, Bello C. Semisynthesis of Homogeneous, Active Granulocyte Colony-Stimulating Factor Glycoforms. Angewandte Chemie (International Edition). 2022 Sep 26;61(39):1-10. e202206116. doi: 10.1002/anie.202206116
Epasto LM, Honegger P, Che K, Kozak F, Jörg F, Schröder C et al. Nuclear Overhauser spectroscopy in hyperpolarized water - chemical vs. magnetic exchange. Chemical Communications. 2022 Sep;58(83):11661-11664. doi: 10.1039/d2cc03735a
Epasto LM, Che K, Kozak F, Selimovic A, Kaderavek P, Kurzbach D. Toward protein NMR at physiological concentrations by hyperpolarized water-Finding and mapping uncharted conformational spaces. Science Advances. 2022 Aug 5;8(31):eabq5179. doi: 10.1126/sciadv.abq5179
Hering A, Emidio NB, Muttenthaler M. Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. Chemical Communications. 2022 Jul 26;58(65):9100-9103. doi: 10.1039/d2cc03752a
Kouhnavardi S, Ecevitoglu A, Dragacevic V, Sanna F, Arias-Sandoval E, Kalaba P et al. A Novel and Selective Dopamine Transporter Inhibitor, (S)-MK-26, Promotes Hippocampal Synaptic Plasticity and Restores Effort-Related Motivational Dysfunctions. Biomolecules. 2022 Jul;12(7):881. doi: 10.3390/biom12070881
Liu H, Muttenthaler M. High Oxytocin Receptor Expression Linked to Increased Cell Migration and Reduced Survival in Patients with Triple-Negative Breast Cancer. Biomedicines. 2022 Jul;10(7):1595. doi: 10.3390/biomedicines10071595
Hering A, Jieu B, Jones A, Muttenthaler M. Approaches to Improve the Quantitation of Oxytocin in Human Serum by Mass Spectrometry. Frontiers in Chemistry. 2022 Jun 9;10:889154. doi: 10.3389/fchem.2022.889154
Negroni M, Guarin D, Che K, Epasto LM, Turhan E, Selimovic A et al. Inversion of Hyperpolarized
13C NMR Signals through Cross-Correlated Cross-Relaxation in Dissolution DNP Experiments. Journal of Physical Chemistry B. 2022 Jun 8;126(24):4599-4610. doi: 10.1021/acs.jpcb.2c03375
Kulkarni SS, Watson EE, Maxwell JWC, Niederacher G, Johansen-Leete J, Huhmann S et al. Expressed Protein Selenoester Ligation. Angewandte Chemie (International Edition). 2022 May 9;61(20):e202200163. doi: 10.1002/anie.202200163
Hilty C, Kurzbach D, Frydman L. Hyperpolarized water as universal sensitivity booster in biomolecular NMR. Nature Protocols. 2022 May;17(7):1621-1657. doi: 10.1038/s41596-022-00693-8
Kremsmayr T, Aljnabi A, Blanco-Canosa JB, Tran HNT, Emidio NB, Muttenthaler M. On the Utility of Chemical Strategies to Improve Peptide Gut Stability. Journal of Medicinal Chemistry. 2022 Apr 28;65(8):6191-6206. doi: 10.1021/acs.jmedchem.2c00094
Hanna C, Kriegesmann J, Dowman L, Becker C, Payne RJ. Chemical Synthesis and Semisynthesis of Lipidated Proteins. Angewandte Chemie (International Edition). 2022 Apr 4;61(15):e202111266. doi: 10.1002/anie.202111266
Klein K, Garkov D, Rütschlin S, Böttcher T, Schreiber F. QSDB—a graphical Quorum Sensing Database. Database: The Journal of Biological Databases and Curation. 2021 Nov 26;2021:baab058. doi: 10.1093/database/baab058
Böttcher T, Nguyen THN, Szamosvari D. Synthesis of bacterial 2-alkyl-4(1H)-quinolone derivatives. ARKIVOC. 2021 Nov 12;2021(9):218-239. doi: 10.24820/ark.5550190.p011.547
Muratspahic E, Retzl B, Dürrauer L, Freissmuth M, Becker CFW, Gruber CW. Genome Mining-Based Discovery of Blenny Fish-Derived Peptides Targeting the Mouse κ-Opioid Receptor. Frontiers in Pharmacology. 2021 Oct 22;12:773029. doi: 10.3389/fphar.2021.773029
Negroni M, Kurzbach D. Residue-resolved monitoring of protein hyperpolarization at sub-second time resolution. Communications Chemistry. 2021 Oct 22;4(1):147. doi: 10.1038/s42004-021-00587-y
Bialas F, Reichinger D, Becker CFW. Biomimetic and biopolymer-based enzyme encapsulation. Enzyme and microbial Technology. 2021 Oct;150:109864. doi: 10.1016/j.enzmictec.2021.109864