Publications Institut of Biological Chemistry (founded 2011)
Turhan E, Minaei M, Narwal P, Meier B, Kouřil K, Kurzbach D. Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization. Communications Chemistry. 2024 Dec;7(1):210. doi: 10.1038/s42004-024-01300-5
Pereira FC, Ge X, Kristensen JM, Kirkegaard RH, Maritsch K, Szamosvári D et al. The Parkinson's disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration. Nature Microbiology. 2024 Dec;9(12):3165–3183. Epub 2024 Nov 21. doi: 10.1038/s41564-024-01853-0
Baldensperger T, Jung T, Heinze T, Schwerdtle T, Höhn A, Grune T. The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death. Free Radical Biology and Medicine. 2024 Nov 20;225:871-880. doi: 10.1016/j.freeradbiomed.2024.10.311
Jandl B, Dighe S, Baumgartner M, Makristathis A, Gasche C, Muttenthaler M. Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies. Gastroenterology. 2024 Nov;167(6):1098-1112.e5. doi: 10.1053/j.gastro.2024.04.032
Kremsmayr T, Schober G, Kaltenböck M, Hoare BL, Brierley SM, Muttenthaler M. Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie - International Edition. 2024 Nov. Epub 2024 Nov. doi: 10.1002/anie.202415333
Turhan E, Goldberga I, Pötzl C, Keil W, Guigner JM, Haßler MFT et al. Branched Polymeric Prenucleation Assemblies Initiate Calcium Phosphate Precipitation. Journal of the American Chemical Society. 2024 Sept 18;146(37):25614-25624. Epub 2024. doi: 10.1021/jacs.4c07325
Jandl B, Dighe S, Gasche C, Makristathis A, Muttenthaler M. Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews. 2024 Sept 12;37(3):e0013323. 00133-23. Epub 2024 Jul 12. doi: 10.1128/cmr.00133-23
Jandl B, Zheng R, Muttenthaler M, Baell J. Novel Diacyl-hydrazide Compounds as Potential Therapeutics for Visceral Leishmaniasis. ACS Omega. 2024 Sept 3;9(35):37170-37182. Epub 2024 Aug 22. doi: 10.1021/acsomega.4c04517
Steuer J, Sinn M, Eble F, Rütschlin S, Böttcher T, Hartig JS et al. Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch. NAR Genomics and Bioinformatics. 2024 Sept 1;6(3):lqae132. doi: 10.1093/nargab/lqae132
Savchenko V, Jaegers M, Rasche R, Herrmann E, König S, Kümmel D et al. Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis. Cell Reports Physical Science. 2024 Aug 21;5(8):102100. Epub 2024 Jul 10. doi: 10.1016/j.xcrp.2024.102100
Kozak F, Brandis D, Pötzl C, Epasto LM, Reichinger D, Obrist D et al. An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation. Advanced science. 2024 Aug 14;11(30):2401239. Epub 2024. doi: 10.1002/advs.202401239
Zachrdla M, Turhan E, Pötzl C, Sadet A, Vasos PR, Kurzbach D. Hyperpolarized nuclear Overhauser enhancement of alanine methyl groups by doubly relayed proton exchange. Journal of Magnetic Resonance. 2024 Jul;364:107727. doi: 10.1016/j.jmr.2024.107727
Tomašević N, Emser FS, Muratspahić E, Gattringer J, Hasinger S, Hellinger R et al. Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor. Journal of Biological Chemistry. 2024 Jun;300(6):107330. doi: 10.1016/j.jbc.2024.107330
Epasto LM, Maimbourg T, Rosso A, Kurzbach D. Unified understanding of the breakdown of thermal mixing dynamic nuclear polarization: The role of temperature and radical concentration. Journal of Magnetic Resonance. 2024 May;362:107670. doi: 10.1016/j.jmr.2024.107670
Schmid A, Bello C, Becker CFW. Synthesis of N-Glycosylated Soluble Fas Ligand. Chemistry - A European Journal. 2024 Apr 25;30(24):e202400120. Epub 2024 Feb 16. doi: 10.1002/chem.202400120
Perisic M, Woolcock K, Hering A, Mendel H, Muttenthaler M. Oxytocin and vasopressin signaling in health and disease. Trends in Biochemical Sciences. 2024 Apr;49(4):361-377. doi: 10.1016/j.tibs.2024.01.010
Mengrelis K, Niederacher G, Prickler L, Kainz V, Weijler AM, Rudolph E et al. Coupling of a Major Allergen to the Surface of Immune Cells for Use in Prophylactic Cell Therapy for the Prevention of IgE-Mediated Allergy. Cells. 2024 Mar;13(5):446. doi: 10.3390/cells13050446
Vogl DP, Mateos B, Migotti M, Felkl M, Conibear AC, Konrat R et al. Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail. Bioorganic and Medicinal Chemistry. 2024 Feb 15;100:117617. doi: 10.1016/j.bmc.2024.117617
Kalaba P, Sanchez de la Rosa C, Möller A, Alewood PF, Muttenthaler M. Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers. Journal of Medicinal Chemistry. 2024 Feb 8;67(3):1625-1640. doi: 10.1021/acs.jmedchem.3c01089
Epasto LM, Pötzl C, Peterlik H, Khalil M, Saint-Pierre C, Gasparutto D et al. NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X. Protein Science. 2024 Jan;33(1):e4849. doi: 10.1002/pro.4849
Orgler E, Baumgartner M, Duller S, Kumptisch C, Hausmann B, Moser D et al. Archaea influence composition of endoscopically visible ileocolonic biofilms. Gut microbes. 2024;16(1):2359500. doi: 10.1080/19490976.2024.2359500
Mou S, Savchenko V, Filz V, Böttcher T, DeShazer D. Burkholderia pseudomallei produces 2-alkylquinolone derivatives important for host virulence and competition with bacteria that employ naphthoquinones for aerobic respiration. Frontiers in Microbiology. 2024;15:1474033. doi: 10.3389/fmicb.2024.1474033
Gajsek O, Becker CFW, Conibear AC. Site-specifically Phosphorylated Hsp90C-terminal Domain Variants Provide Access to Deciphering the Chaperone Code. Chemistry - A European Journal. 2024. Epub 2024. doi: 10.1002/chem.202403676
Kratzwald S, Schwarz TC, Ledolter K, Hlavac M, Felkl M, Becker CFW et al. Synthesis of a 13C/2H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy. ChemBioChem. 2024. Epub 2024. doi: 10.1002/cbic.202400663
Savchenko V, Szamosvári D, Bao Y, Pignitter M, Böttcher T. Biosynthetic flexibility of Pseudomonas aeruginosa leads to hydroxylated 2-alkylquinolones with proinflammatory host response. Communications Chemistry. 2023 Dec;6(1):138. doi: 10.1038/s42004-023-00937-y
Dunajova Z, Mateu BP, Radler P, Lim K, Brandis D, Velicky P et al. Chiral and nematic phases of flexible active filaments. Nature Physics. 2023 Dec;19(12):1916-1926. doi: 10.1038/s41567-023-02218-w
Spreitzer I, Keife J, Strasser T, Kalaba P, Lubec J, Neuhaus W et al. Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution. International Journal of Molecular Sciences. 2023 Dec;24(23):16956. doi: 10.3390/ijms242316956
Muratspahić E, Deibler K, Han J, Tomašević N, Jadhav KB, Olivé-Marti AL et al. Design and structural validation of peptide–drug conjugate ligands of the kappa-opioid receptor. Nature Communications. 2023 Nov 28;14(1):8064. doi: 10.1038/s41467-023-43718-w
Wirth U, Raabe K, Kalaba P, Keimpema E, Muttenthaler M, König B. Photoswitchable Probes of Oxytocin and Vasopressin. Journal of Medicinal Chemistry. 2023 Nov 9;66(21):14853-14865. doi: 10.1021/acs.jmedchem.3c01415
Turhan E, Pötzl C, Keil W, Negroni M, Kouřil K, Meier B et al. Biphasic NMR of Hyperpolarized Suspensions-Real-Time Monitoring of Solute-to-Solid Conversion to Watch Materials Grow. The Journal of Physical Chemistry Part C (Nanomaterials and Interfaces). 2023 Oct 5;127(39):19591-19598. doi: 10.1021/acs.jpcc.3c04198
Ückert AK, Rütschlin S, Gutbier S, Wörz NC, Miah MR, Martins AC et al. Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration. Environment International. 2023 Oct 3;180:108229. doi: 10.1016/j.envint.2023.108229
Kalaba P, Pacher K, Neill PJ, Dragacevic V, Zehl M, Wackerlig J et al. Chirality Matters: Fine-Tuning of Novel Monoamine Reuptake Inhibitors Selectivity through Manipulation of Stereochemistry. Biomolecules. 2023 Sept;13(9):1415. doi: 10.3390/biom13091415
Schrems M, Kravchuk A, Niederacher G, Exler F, Bello C, Becker CFW. Light-Cleavable Auxiliary for Diselenide–Selenoester Ligations of Peptides and Proteins. Chemistry - A European Journal. 2023 Aug 15;29(46):e202301253. doi: 10.1002/chem.202301253
Kriegesmann J, Schlatzer T, Che K, Altdorf C, Huhmann S, Kählig H et al. Constraining and Modifying Peptides Using Pd-Mediated Cysteine Allylation. ChemBioChem. 2023 Jul 3;24(13):e202300098. doi: 10.1002/cbic.202300098
Mukherjee S, Vogl DP, Becker CFW. Site-Specific Glycation of Human Heat Shock Protein (Hsp27) Enhances Its Chaperone Activity. ACS Chemical Biology. 2023 Jul;18(8):1760-1771. doi: 10.1021/acschembio.3c00214
Bello C, Pranzini E, Piemontese E, Schrems M, Taddei ML, Giovannelli L et al. Chemoenzymatic Synthesis of Glycopeptides to Explore the Role of Mucin 1 Glycosylation in Cell Adhesion. ChemBioChem. 2023 Jun 15;24(12):e202200741. doi: 10.1002/cbic.202200741
Szamosvari D, Savchenko V, Badouin N, Böttcher T. Beyond iron: metal-binding activity of the Pseudomonas quinolone signal-motif. Organic & Biomolecular Chemistry. 2023 May 30;21(25):5158-5163. doi: 10.1039/d3ob00710c
Ghatage T, Singh S, Mandal K, Jadhav KB, Dhar A. Activation of Mas and pGCA receptor pathways protects renal epithelial cell damage against oxidative-stress-induced injury. Peptides. 2023 Apr;162:170959. doi: 10.1016/j.peptides.2023.170959
Strobl J, Kozak F, Kamalov M, Reichinger D, Kurzbach D, Becker CFW. Understanding Self-Assembly of Silica-Precipitating Peptides to Control Silica Particle Morphology. Advanced Materials. 2023 Mar 16;35(11):2207586. doi: 10.1002/adma.202207586
Grant PS, Cruz Meyrelles RJ, Gajsek O, Niederacher G, Maryasin B, Maulide N. Biomimetic Cationic Cyclopropanation Enables an Efficient Chemoenzymatic Synthesis of 6,8-Cycloeudesmanes. Journal of the American Chemical Society. 2023 Mar 15;145(10):5855-5863. doi: 10.1021/jacs.2c13116
Negroni M, Kurzbach D. Missing Pieces in Structure Puzzles: How Hyperpolarized NMR Spectroscopy Can Complement Structural Biology and Biochemistry. ChemBioChem. 2023 Mar 14;24(6):e202200703. doi: 10.1002/cbic.202200703
Lubec J, Hussein AM, Kalaba P, Feyissa DD, Arias-Sandoval E, Cybulska-Klosowicz A et al. Low-Affinity/High-Selectivity Dopamine Transport Inhibition Sufficient to Rescue Cognitive Functions in the Aging Rat. Biomolecules. 2023 Mar 3;13(3):467. doi: 10.3390/biom13030467
Reichinger D, Reithofer M, Hohagen M, Drinic M, Tobias J, Wiedermann U et al. A Biomimetic, Silaffin R5-Based Antigen Delivery Platform. Pharmaceutics. 2023 Jan;15(1):121. doi: 10.3390/pharmaceutics15010121
Dowman LJ, Kulkarni SS, Alegre-Requena J, Giltrap AM, Norman AR, Sharma A et al. Site-selective photocatalytic functionalization of peptides and proteins at selenocysteine. Nature Communications. 2022 Nov 12;13(1):6885. doi: 10.1038/s41467-022-34530-z
Negroni M, Turhan E, Kress T, Ceillier M, Jannin S, Kurzbach D. Frémy's Salt as a Low-Persistence Hyperpolarization Agent: Efficient Dynamic Nuclear Polarization Plus Rapid Radical Scavenging. Journal of the American Chemical Society. 2022 Nov;144(45):20680-20686. doi: 10.1021/jacs.2c07960
Hengxi Z, Modenutti C, Nekkanti YPK, Denis M, Bermejo IA, Lefèbre J et al. Identification of the Allosteric Binding Site for Thiazolopyrimidine on the C-Type Lectin Langerin. ACS Chemical Biology. 2022 Oct 21;17(10):2728–2733. Epub 2022 Sept 26. doi: 10.1021/acschembio.2c00626
Kerul L, Schrems M, Schmid A, Meli R, Becker CFW, Bello C. Semisynthesis of Homogeneous, Active Granulocyte Colony-Stimulating Factor Glycoforms. Angewandte Chemie (International Edition). 2022 Sept 26;61(39):1-10. e202206116. doi: 10.1002/anie.202206116
Epasto LM, Honegger P, Che K, Kozak F, Jörg F, Schröder C et al. Nuclear Overhauser spectroscopy in hyperpolarized water - chemical vs. magnetic exchange. Chemical Communications. 2022 Sept;58(83):11661-11664. doi: 10.1039/d2cc03735a
Epasto LM, Che K, Kozak F, Selimovic A, Kaderavek P, Kurzbach D. Toward protein NMR at physiological concentrations by hyperpolarized water-Finding and mapping uncharted conformational spaces. Science Advances. 2022 Aug 5;8(31):eabq5179. doi: 10.1126/sciadv.abq5179
Hering A, Emidio NB, Muttenthaler M. Expanding the versatility and scope of the oxime ligation: rapid bioconjugation to disulfide-rich peptides. Chemical Communications. 2022 Jul 26;58(65):9100-9103. doi: 10.1039/d2cc03752a