Publications

Arrowsmith S, Keov P, Muttenthaler M, Gruber CW. Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development. Journal of Visualized Experiments. 2018 Jan;2018(131):e56639. doi: 10.3791/56639

Matveenko M, Hackl S, Becker CFW. Utility of the Phenacyl Protecting Group in Traceless Protein Semisynthesis through Ligation-Desulfurization Chemistry. ChemistryOpen. 2018 Jan;7(1):106-110. doi: 10.1002/open.201700180

Brehs M, Poetgens AJG, Steitz J, Thewes K, Schwarz J, Conibear AC et al. Synthetic integrin-binding immune stimulators target cancer cells and prevent tumor formation. Scientific Reports. 2017 Dec 14;7:17592. doi: 10.1038/s41598-017-17627-0

Muttenthaler M, Andersson A, Vetter I, Menon R, Busnelli M, Ragnarsson L et al. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling. 2017 Dec 5;10(508):eaan3398. doi: 10.1126/scisignal.aan3398

Gell AL, Groysbeck N, Becker CFW, Conibear AC. A comparative study of synthetic and semisynthetic approaches for ligating the epidermal growth factor to a bivalent scaffold. Journal of Peptide Science. 2017 Dec;23(12):871-879. doi: 10.1002/psc.3051

Hellinger R, Thell K, Vasileva M, Muhammad T, Gunasekera S, Kuemmel D et al. Chemical Proteomics for Target Discovery of Head-to-Tail Cyclized Mini-Proteins. Frontiers in Chemistry. 2017 Oct 11;5:73. doi: 10.3389/fchem.2017.00073

Pasalic D, Weber B, Giannone C, Anelli T, Mller R, Fagioli C et al. A peptide extension dictates IgM assembly. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2017 Oct 10;114(41):E8575-E8584. doi: 10.1073/pnas.1701797114

Conibear AC, Hager S, Mayr J, Klose MHM, Keppler BK , Kowol CR et al. Multifunctional α _vβ ₆ Integrin-Specific Peptide-Pt(IV) Conjugates for Cancer Cell Targeting. Bioconjugate Chemistry. 2017 Sep 20;28(9):2429-2439. doi: 10.1021/acs.bioconjchem.7b00421

Bello C, Becker CFW. A dual functional peptide-auxiliary conjugate for C-to-N and N-to-C sequential native chemical ligation of glycopeptides. Bioorganic & Medicinal Chemistry. 2017 Sep 15;25(18):5016-5021. doi: 10.1016/j.bmc.2017.05.046

Matveenko M, Becker CFW. Synthetic Approach to Argpyrimidine as a Tool for Investigating Nonenzymatic Posttranslational Modification of Proteins. Synlett: accounts and rapid communications in synthetic organic chemistry. 2017 Sep;28(15):1950-1955. doi: 10.1055/s-0036-1588225

Araman C, Thompson RE, Wang S, Hackl S, Payne RJ, Becker CFW. Semisynthetic prion protein (PrP) variants carrying glycan mimics at position 181 and 197 do not form fibrils. Chemical Science. 2017 Jul 24;8(9):6626-6632. doi: 10.1039/c7sc02719b

Kaur H, Kamalov M, Brimble MA. Chemical Synthesis of Peptides Containing Site-Specific Advanced Glycation Endproducts. Accounts of Chemical Research. 2016 Oct 18;49(10):2199-2208. doi: 10.1021/acs.accounts.6b00366

Schwaighofer A, Alcaraz MR, Araman MC, Goicoechea H, Lendl B. External cavity-quantum cascade laser infrared spectroscopy for secondary structure analysis of proteins at low concentrations. Scientific Reports. 2016 Sep 16;6:33556. doi: 10.1038/srep33556

Matveenko M, Cichero E, Fossa P, Becker CFW. Impaired Chaperone Activity of Human Heat Shock Protein Hsp27 Site-Specifically Modified with Argpyrimidine. Angewandte Chemie (International Edition). 2016 Sep 12;55(38):11397-11402. doi: 10.1002/anie.201605366

Aladini F, Araman MC, Becker CFW. Chemical synthesis and characterization of elastin-like polypeptides (ELPs) with variable guest residues. Journal of Peptide Science. 2016 May;22(5):334-342. doi: 10.1002/psc.2871

Koehbach J, Gruber CW, Becker C, Kreil DP, Jilek A. MALDI TOF/TOF-Based Approach for the Identification of D- Amino Acids in Biologically Active Peptides and Proteins. Journal of Proteome Research. 2016 May;15(5):1487-1496. doi: 10.1021/acs.jproteome.5b01067

Martelli T, Ravera E, Louka A, Cerofolini L, Hafner M, Fragai M et al. Atomic-Level Quality Assessment of Enzymes Encapsulated in Bioinspired Silica. Chemistry: A European Journal. 2016 Jan 4;22(1):425-432. doi: 10.1002/chem.201503613

Conibear AC, Chaousis S, Durek T, Rosengren KJ, Craik DJ, Schroeder CI. Approaches to the Stabilization of Bioactive Epitopes by Grafting and Peptide Cyclization. Biopolymers: original research on biological molecules and assemblies. 2016 Jan;106(1):89-100. doi: 10.1002/bip.22767

Conibear AC, Farbiarz K, Mayer RL, Matveenko M, Kählig H , Becker CFW. Arginine side-chain modification that occurs during copper-catalysed azide-alkyne click reactions resembles an advanced glycation end product. Organic & Biomolecular Chemistry. 2016;14(26):6205-6211. doi: 10.1039/c6ob00932h

Lechner CC, Becker CFW. Silaffins in Silica Biomineralization and Biomimetic Silica Precipitation. Marine Drugs. 2015 Aug;13(8):5297-5333. doi: 10.3390/md13085297

Bello C, Wang S, Meng L, Moremen KW, Becker CFW. A PEGylated Photocleavable Auxiliary Mediates the Sequential Enzymatic Glycosylation and Native Chemical Ligation of Peptides. Angewandte Chemie (International Edition). 2015 Jun 22;54(26):7711-7715. doi: 10.1002/anie.201501517

Bello C, Kikul F, Becker CFW. Efficient generation of peptide hydrazides via direct hydrazinolysis of Peptidyl-Wang-TentaGel resins. Journal of Peptide Science. 2015 Mar;21(3):201-207. doi: 10.1002/psc.2747

Lechner CC, Becker CFW. Immobilising proteins on silica with site-specifically attached modified silaffin peptides. Biomaterials Science. 2015;3(2):288-297. doi: 10.1039/c4bm00310a

Chu NK, Shabbir W, Bove-Fenderson E, Araman MC, Lemmens R, Harris DA et al. A C-terminal Membrane Anchor Affects the Interactions of Prion Proteins with Lipid Membranes. Journal of Biological Chemistry. 2014 Oct 24;289(43):30144-30160. doi: 10.1074/jbc.M114.587345

Schwaighofer A, Pechlaner M, Oostenbrink C, Kotlowski C, Araman MC, Mastrogiacomo R et al. Insights into structural features determining odorant affinities to honey bee odorant binding protein 14. Biochemical and Biophysical Research Communications. 2014 Apr 18;446(4):1042-1046. doi: 10.1016/j.bbrc.2014.03.054

Bello C, Farbiarz K, Moeller JF, Becker CFW, Schwientek T. A quantitative and site-specific chemoenzymatic glycosylation approach for PEGylated MUC1 peptides. Chemical Science. 2014 Apr;5(4):1634-1641. doi: 10.1039/c3sc52641k

Schwaighofer A, Kotlowski C, Araman MC, Chu N, Mastrogiacomo R, Becker C et al. Honey bee odorant-binding protein 14: effects on thermal stability upon odorant binding revealed by FT-IR spectroscopy and CD measurements. European Biophysics Journal. 2014 Mar;43(2-3):105-112. doi: 10.1007/s00249-013-0939-4

Lechner CC, Becker CFW. A sequence-function analysis of the silica precipitating silaffin R5 peptide. Journal of Peptide Science. 2014 Feb;20(2):152-158. doi: 10.1002/psc.2577

Tripsianes K, Chu NK, Friberg A, Sattler M, Becker CFW. Studying Weak and Dynamic Interactions of Posttranslationally Modified Proteins using Expressed Protein Ligation. ACS Chemical Biology. 2014 Feb;9(2):347-352. doi: 10.1021/cb400723j

Rauh D, Fischer F, Gertz M, Lakshminarasimhan M, Bergbrede T, Aladini F et al. An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms. Nature Communications. 2013 Sep;4:2327. doi: 10.1038/ncomms3327

Marcinowski M, Rosam M, Seitz C, Elferich J, Behnke J, Bello C et al. Conformational Selection in Substrate Recognition by Hsp70 Chaperones. Journal of Molecular Biology. 2013 Feb 8;425(3):466-474. doi: 10.1016/j.jmb.2012.11.030

Lechner C, Becker CFW. Modified silaffin R5 peptides enable encapsulation and release of cargo molecules from biomimetic silica particles. Bioorganic & Medicinal Chemistry. 2013;21(12):3533-3541. doi: 10.1016/j.bmc.2013.04.006

Gogolin L, Schroeder H, Itzen A, Goody RS, Niemeyer CM, Becker CFW. Protein-DNA Arrays as Tools for Detection of Protein-Protein Interactions by Mass Spectrometry. ChemBioChem: a european journal of chemical biology. 2013;14(1):92-99. doi: 10.1002/cbic.201200597

Chu N, Becker CFW. Recombinant expression of soluble murine prion protein for C-terminal modification. FEBS Letters. 2013;587(5):430-435. doi: 10.1016/j.febslet.2012.12.026

Gertz M, Giang TTN, Fischer F, Suenkel B, Schlicker C, Fraenzel B et al. A Molecular Mechanism for Direct Sirtuin Activation by Resveratrol. PLoS ONE. 2012;7(11). doi: 10.1371/journal.pone.0049761

Lechner C, Becker CFW. Exploring the effect of native and artificial peptide modifications on silaffin induced silica precipitation. Chemical Science. 2012;3(12):3500-3504. doi: 10.1039/c2sc20687k

Hong G-S, Chen C-P, Lin M-H, Krueger J, Becker CFW, Fink RHA et al. Molecular dynamics simulations and conductance studies of the interaction of VP1 N-terminus from Polio virus and gp41 fusion peptide from HIV-1 with lipid membranes. Molecular Membrane Biology. 2012;29(1):9-25. doi: 10.3109/09687688.2011.644589

Stein ML, Beck P, Kaiser M, Dudler R, Becker CFW, Groll M. One-shot NMR analysis of microbial secretions identifies highly potent proteasome inhibitor. Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2012;109(45):18367-18371. doi: 10.1073/pnas.1211423109

Brehs M, Bäuml K, Becker CFW. Chemical Synthesis of an Integral Membrane Enzyme u The Challenges of Diacylglycerol Kinase. Israel Journal of Chemistry. 2011;51(8-9):930-939. doi: 10.1002/ijch.201100090

Weber M, Prodoehl A, Dreher C, Becker CFW, Underhaug J, Svane ASP et al. SDS-facilitated in vitro formation of a transmembrane B-type cytochrome is mediated by changes in local pH. Journal of Molecular Biology. 2011;407(4):594-606. doi: 10.1016/j.jmb.2011.02.005

Lahiri S, Brehs M, Olschewski D, Becker CFW. Total Chemical Synthesis of an Integral Membrane Enzyme: Diacylglycerol Kinase from Escherichia coli. Angewandte Chemie (International Edition). 2011;50(17):3988-3992. doi: 10.1002/anie.201006686

Gille L, Stamberg W, Gregor W, Jäger W , Reznicek G, Netscher T et al. Ubichromanol: A prodrug to support mitochondrial ubiquinone functions? BioFactors. 2008 Jan 1;32(1-4):83-90. doi: 10.1002/biof.5520320110

Publications Institut of Biological Chemistry (founded 2011)