Publications Institut of Biological Chemistry (founded 2011)
Sirivibulkovit K, Voelkle J, Windisch DJ, Muttenthaler M, Lieberzeit PA, Saetear P. Electrochemical dengue sensor based on NS1 epitope-imprinted polymers. Biosensors and Bioelectronics. 2025 Dec 1;289:117915. doi: 10.1016/j.bios.2025.117915
Cinquina V, Tretiakov EO, Kalaba P, Alpár A, Calvigioni D, Piscitelli F et al. Astrocytes modulate neuronal development by S100A6 signaling. Nature Communications. 2025 Dec;16(1):9049. doi: 10.1038/s41467-025-64405-y
Schlatzer T, Kriegesmann J, Bieber M, Becker CFW, Breinbauer R. Hydrophilic BIPHEPHOS Ligand for Pd-Mediated Cysteine Allylation of Peptides and Proteins in Water. Organic Letters. 2025 Nov 21;27(46):12813-12818. doi: 10.1021/acs.orglett.5c04112
Ning Y, Efrém NL, Amoussa M, Turhan E, Zheng D, Lefèbre J et al. Calcium Competitive Inhibition of Langerin by Thiazolopyrimidinones. Journal of Medicinal Chemistry. 2025 Nov 19. doi: 10.1021/acs.jmedchem.5c01756
Pascali G, Parmar A, Zanoni S, Arthur A, Hering A, Teakle N et al. Development and characterisation of novel oxytocin analogues for PET imaging. Communications Chemistry. 2025 Nov 5;8(1):328. doi: 10.1038/s42004-025-01649-1
Venkadakrishnan J, Vemana A, Ghatage T, Vesmaker K, Bhat A, Jadhav KB et al. Therapeutic Peptides Mitigates TLR4 Pathway Activation by Ang II in Renal and Vascular Smooth Muscle Cells. Journal of biochemical and molecular toxicology. 2025 Nov;39(11):e70579. doi: 10.1002/jbt.70579
Denisov SS, Bialek EL, Beretta F, Smagurauskaite G, Ippel H, Fijlstra E et al. Chemokine-Binding All-D-CLIPS Peptides Identified Using Mirror-Image Phage Display. ACS Chemical Biology. 2025 Oct 28. Epub 2025 Oct 28. doi: 10.1021/acschembio.5c00726
Plöchl K, Böttcher T. A novel class of small-molecule inhibitors targeting bacteriophage infection. RSC Chemical Biology. 2025 Oct 27. Epub 2025 Oct 27. doi: 10.1039/d5cb00120j
Turhan E, Pötzl C, Brandis D, Faglia F, Zachrdla M, Kurzbach D. Deep Learning for Hyperpolarized NMR of Intrinsically Disordered Proteins Without Resolution Loss: Access to Short-Lived Intermediates. Chemistry - A European Journal. 2025 Oct 22;31(59):e02067. Epub 2025. doi: 10.1002/chem.202502067
Brandis D, Turhan E, Zachrdla M, Kurzbach D. Residue-Resolved Liquid-State Hyperpolarized NMR of Peptide Condensate Surfaces. Journal of the American Chemical Society. 2025 Oct 8;147(40):36920-36927. doi: 10.1021/jacs.5c15053
Perisic Böhm M, Kalaba P, Gormal RS, Zupančič M, Wolf A, Juračić M et al. Fluorescent Peptide Tracers for Simultaneous Oxytocin Receptor Activation and Visualization. Angewandte Chemie (International ed. in English). 2025 Sept 26;e202515180. Epub 2025 Sept 26. doi: 10.1002/anie.202515180
Pötzl C, Turhan E, Gervais C, Azaïs T, Kurzbach D. Hyperpolarized NMR Combined with Quantum Mechanical Simulations Reveal Atomistic Structures of Calcium Phosphate Prenucleation Clusters. Analytical Chemistry. 2025 Sept. Epub 2025 Sept. doi: 10.1021/acs.analchem.5c02945
Tocino-Márquez I, Zehl M, Séneca J, Pjevac P, Felkl M, Becker CFW et al. The bacterial community of the freshwater bryozoan Cristatella Mucedo and its secondary metabolites production potential. Scientific Reports. 2025 Aug 26;15(1):31456. doi: 10.1038/s41598-025-17084-0
Weissinger H, Urschbach M, Ferrari L, Martens S, Becker CFW. Photocatalytic Diselenide Contraction as a Tool for Site-Selective Isosteric Ubiquitylation. Journal of Peptide Science. 2025 Aug;31(8):e70037. doi: 10.1002/psc.70037
Rasoulimehrabani H, Riva A, Inan D, Hodžić A, Hausmann B, Nikolov G et al. Lactulose selectively stimulates members of the gut microbiota, as determined by multi-modal activity-based sorting. Gut microbes. 2025 Jun 27;17(1):2525482. doi: 10.1080/19490976.2025.2525482
Urschbach M, Huhmann S, Appel D, Ferrari L, Vogl D, Martens S et al. Convergent Assembly of Homo- and Heterotypic Ubiquitin Chains from Functionalized, Expressed Monomers via Thiol-Ene Chemistry. Angewandte Chemie - International Edition. 2025 May 19;64(21):e202502638. Epub 2025 Mar 15. doi: 10.1002/anie.202502638
Ostrovitsa N, Williams C, Raabe K, McLean JT, Muttenthaler M, Scanlan EM. An Efficient Thiol-ene Mediated Protocol for Thiolated Peptide Synthesis and On-Resin Diversification. Chemistry: A European Journal. 2025 May 15;31(36):e202501372. Epub 2025 May 15. doi: 10.1002/chem.202501372
Brandis D, Mollica G, Kurzbach D. R5 Peptides Constitute Condensed Phases with Liquid-Like Properties in Biomimetic Silica Capsules. Journal of Physical Chemistry Letters. 2025 May 1;16(17):4326-4335. doi: 10.1021/acs.jpclett.5c00144
Makarov SE, Vujisić L, Raspotnig G, Antić D, Anderl F, Krstić G et al. Scenting Ketones in the Defense Glands of Two Julids From the Caucasus (Arthropoda, Myriapoda, Diplopoda, Julida). Journal of Chemical Ecology. 2025 Apr 29;51(3):50. 50. doi: 10.1007/s10886-025-01603-4
Savchenko V, Yu XA, Polz MF, Böttcher T. Chitinivorax: The New Kid on the Block of Bacterial 2-Alkyl-4(1H)-quinolone Producers. ACS Chemical Biology. 2025 Apr 18;20(4):960-966. Epub 2025. doi: 10.1021/acschembio.5c00046
Mix AK, Nguyen THN, Schuhmacher T, Szamosvári D, Muenzner P, Haas P et al. A quinolone N-oxide antibiotic selectively targets Neisseria gonorrhoeae via its toxin–antitoxin system. Nature Microbiology. 2025 Apr;10(4):939-957. 35. doi: 10.1038/s41564-025-01968-y
Elmaci DN, Hopping G, Hoffmann W, Muttenthaler M, Stein M. The structural integrity of human TFF1 under reducing conditions. Redox biology. 2025 Apr;81:103534. doi: 10.1016/j.redox.2025.103534
Burger I, Schmal M, Peikert K, Fourtis L, Suster C, Stanetty C et al. Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei. Biotechnology for biofuels and bioproducts. 2025 Mar 11;18(1):32. doi: 10.1186/s13068-025-02628-3
Brandis D, Kaderávek P, Kurzbach D. The Internal Structural Dynamics of Elastin-Like Polypeptide Assemblies by 13C‑Direct Detected NMR Spectroscopy. Analytical Chemistry. 2025 Feb 25;97(7):3937-3944. doi: 10.1021/acs.analchem.4c05163
Kratzwald S, Schwarz TC, Ledolter K, Hlavac M, Felkl M, Becker CFW et al. Synthesis of a 13C/2H Labeled Building Block to Probe the Phosphotyrosine Interactome Using Biomolecular NMR Spectroscopy. ChemBioChem. 2025 Jan 2;26(1):e202400663. Epub 2024. doi: 10.1002/cbic.202400663
Sokolova N, Denisov SS, Hackl T, Haslinger K. Unravelling the Functional Diversity of Type III Polyketide Synthases in Fungi. Angewandte Chemie - International Edition. 2025;e202514786. doi: 10.1002/anie.202514786
Kremsmayr T, Schober G, Kaltenböck M, Hoare BL, Brierley SM, Muttenthaler M. Oxytocin Analogues for the Oral Treatment of Abdominal Pain. Angewandte Chemie - International Edition. 2024 Dec 20;63(52):e202415333. Epub 2024 Nov. doi: 10.1002/anie.202415333
Baldensperger T, Preissler M, Becker CFW. Non-enzymatic posttranslational protein modifications in protein aggregation and neurodegenerative diseases. RSC Chemical Biology. 2024 Dec 19;6(2):129-149. Epub 2024. doi: 10.1039/d4cb00221k
Riedl S, Bilgen E, Agam G, Hirvonen V, Jussupow A, Tippl F et al. Evolution of the conformational dynamics of the molecular chaperone Hsp90. Nature Communications. 2024 Dec;15(1):8627. doi: 10.1038/s41467-024-52995-y
Turhan E, Minaei M, Narwal P, Meier B, Kouřil K, Kurzbach D. Short-lived calcium carbonate precursors observed in situ via Bullet-dynamic nuclear polarization. Communications Chemistry. 2024 Dec;7(1):210. doi: 10.1038/s42004-024-01300-5
Pereira FC, Ge X, Kristensen JM, Kirkegaard RH, Maritsch K, Szamosvári D et al. The Parkinson's disease drug entacapone disrupts gut microbiome homoeostasis via iron sequestration. Nature Microbiology. 2024 Dec;9(12):3165–3183. Epub 2024 Nov 21. doi: 10.1038/s41564-024-01853-0
Baldensperger T, Jung T, Heinze T, Schwerdtle T, Höhn A, Grune T. The age pigment lipofuscin causes oxidative stress, lysosomal dysfunction, and pyroptotic cell death. Free Radical Biology and Medicine. 2024 Nov 20;225:871-880. doi: 10.1016/j.freeradbiomed.2024.10.311
Jandl B, Dighe S, Baumgartner M, Makristathis A, Gasche C, Muttenthaler M. Gastrointestinal Biofilms: Endoscopic Detection, Disease Relevance, and Therapeutic Strategies. Gastroenterology. 2024 Nov;167(6):1098-1112.e5. doi: 10.1053/j.gastro.2024.04.032
Turhan E, Goldberga I, Pötzl C, Keil W, Guigner JM, Haßler MFT et al. Branched Polymeric Prenucleation Assemblies Initiate Calcium Phosphate Precipitation. Journal of the American Chemical Society. 2024 Sept 18;146(37):25614-25624. Epub 2024. doi: 10.1021/jacs.4c07325
Jandl B, Dighe S, Gasche C, Makristathis A, Muttenthaler M. Intestinal biofilms: pathophysiological relevance, host defense, and therapeutic opportunities. Clinical microbiology reviews. 2024 Sept 12;37(3):e00133-23. Epub 2024 Jul 12. doi: 10.1128/cmr.00133-23
Jandl B, Zheng R, Muttenthaler M, Baell J. Novel Diacyl-hydrazide Compounds as Potential Therapeutics for Visceral Leishmaniasis. ACS Omega. 2024 Sept 3;9(35):37170-37182. Epub 2024 Aug 22. doi: 10.1021/acsomega.4c04517
Steuer J, Sinn M, Eble F, Rütschlin S, Böttcher T, Hartig JS et al. Cooperative binding of bivalent ligands yields new insights into the guanidine-II riboswitch. NAR Genomics and Bioinformatics. 2024 Sept 1;6(3):lqae132. doi: 10.1093/nargab/lqae132
Savchenko V, Jaegers M, Rasche R, Herrmann E, König S, Kümmel D et al. Unraveling key steps in the biosynthesis of antimicrobial methylated unsaturated 2-alkyl-4-quinolones of Burkholderia thailandensis. Cell Reports Physical Science. 2024 Aug 21;5(8):102100. Epub 2024 Jul 10. doi: 10.1016/j.xcrp.2024.102100
Kozak F, Brandis D, Pötzl C, Epasto LM, Reichinger D, Obrist D et al. An Atomistic View on the Mechanism of Diatom Peptide-Guided Biomimetic Silica Formation. Advanced science. 2024 Aug 14;11(30):2401239. Epub 2024. doi: 10.1002/advs.202401239
Zachrdla M, Turhan E, Pötzl C, Sadet A, Vasos PR, Kurzbach D. Hyperpolarized nuclear Overhauser enhancement of alanine methyl groups by doubly relayed proton exchange. Journal of Magnetic Resonance. 2024 Jul;364:107727. doi: 10.1016/j.jmr.2024.107727
Tomašević N, Emser FS, Muratspahić E, Gattringer J, Hasinger S, Hellinger R et al. Discovery and development of macrocyclic peptide modulators of the cannabinoid 2 receptor. Journal of Biological Chemistry. 2024 Jun;300(6):107330. doi: 10.1016/j.jbc.2024.107330
Epasto LM, Maimbourg T, Rosso A, Kurzbach D. Unified understanding of the breakdown of thermal mixing dynamic nuclear polarization: The role of temperature and radical concentration. Journal of Magnetic Resonance. 2024 May;362:107670. doi: 10.1016/j.jmr.2024.107670
Schmid A, Bello C, Becker CFW. Synthesis of N-Glycosylated Soluble Fas Ligand. Chemistry - A European Journal. 2024 Apr 25;30(24):e202400120. Epub 2024 Feb 16. doi: 10.1002/chem.202400120
Perisic M, Woolcock K, Hering A, Mendel H, Muttenthaler M. Oxytocin and vasopressin signaling in health and disease. Trends in Biochemical Sciences. 2024 Apr;49(4):361-377. doi: 10.1016/j.tibs.2024.01.010
Mengrelis K, Niederacher G, Prickler L, Kainz V, Weijler AM, Rudolph E et al. Coupling of a Major Allergen to the Surface of Immune Cells for Use in Prophylactic Cell Therapy for the Prevention of IgE-Mediated Allergy. Cells. 2024 Mar;13(5):446. doi: 10.3390/cells13050446
Vogl DP, Mateos B, Migotti M, Felkl M, Conibear AC, Konrat R et al. Semisynthesis of segmentally isotope-labeled and site-specifically palmitoylated CD44 cytoplasmic tail. Bioorganic and Medicinal Chemistry. 2024 Feb 15;100:117617. doi: 10.1016/j.bmc.2024.117617
Kalaba P, Sanchez de la Rosa C, Möller A, Alewood PF, Muttenthaler M. Targeting the Oxytocin Receptor for Breast Cancer Management: A Niche for Peptide Tracers. Journal of Medicinal Chemistry. 2024 Feb 8;67(3):1625-1640. doi: 10.1021/acs.jmedchem.3c01089
Epasto LM, Pötzl C, Peterlik H, Khalil M, Saint-Pierre C, Gasparutto D et al. NMR-identification of the interaction between BRCA1 and the intrinsically disordered monomer of the Myc-associated factor X. Protein Science. 2024 Jan;33(1):e4849. doi: 10.1002/pro.4849
Orgler E, Baumgartner M, Duller S, Kumptisch C, Hausmann B, Moser D et al. Archaea influence composition of endoscopically visible ileocolonic biofilms. Gut microbes. 2024;16(1):2359500. doi: 10.1080/19490976.2024.2359500
Mou S, Savchenko V, Filz V, Böttcher T, DeShazer D. Burkholderia pseudomallei produces 2-alkylquinolone derivatives important for host virulence and competition with bacteria that employ naphthoquinones for aerobic respiration. Frontiers in Microbiology. 2024;15:1474033. doi: 10.3389/fmicb.2024.1474033